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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1998-11-30
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pubmed:abstractText |
Three new macrolides, 30-hydroxymycalolide A (4), 32-hydroxymycalolide A (5), and 38-hydroxymycalolide B (6), were isolated from the marine sponge Mycale magellanica. Their structures were assigned on the basis of spectroscopic data. They were cytotoxic against L1210 cells with IC50 values of 0.019, 0.013, and 0.015 microg/mL, respectively. Chemical interconversion of the known mycalolides A-C (1-3) with 4-6 established their stereochemical relationships.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0163-3864
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1164-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9748392-Animals,
pubmed-meshheading:9748392-Antineoplastic Agents,
pubmed-meshheading:9748392-Drug Screening Assays, Antitumor,
pubmed-meshheading:9748392-Leukemia L1210,
pubmed-meshheading:9748392-Macrolides,
pubmed-meshheading:9748392-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9748392-Porifera,
pubmed-meshheading:9748392-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:9748392-Stereoisomerism
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pubmed:year |
1998
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pubmed:articleTitle |
New mycalolides from the marine sponge Mycale magellanica and their interconversion.
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pubmed:affiliation |
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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