| pubmed-article:9746734 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9746734 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9746734 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9746734 | lifeskim:mentions | umls-concept:C0039597 | lld:lifeskim |
| pubmed-article:9746734 | lifeskim:mentions | umls-concept:C0014533 | lld:lifeskim |
| pubmed-article:9746734 | lifeskim:mentions | umls-concept:C0023689 | lld:lifeskim |
| pubmed-article:9746734 | lifeskim:mentions | umls-concept:C0033532 | lld:lifeskim |
| pubmed-article:9746734 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:9746734 | lifeskim:mentions | umls-concept:C0040287 | lld:lifeskim |
| pubmed-article:9746734 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:9746734 | lifeskim:mentions | umls-concept:C0220927 | lld:lifeskim |
| pubmed-article:9746734 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9746734 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9746734 | pubmed:dateCreated | 1998-12-7 | lld:pubmed |
| pubmed-article:9746734 | pubmed:abstractText | The changes in glutathione-independent prostaglandin D2 synthetase (PGD-S) during maturation in the rat were determined in selected organs by an RIA using PGD-S purified from rat cerebrospinal fluid and a monospecific anti-rat PGD-S polyclonal antibody. In a survey of its tissue distribution in various organ extracts and biological fluids, it was found that the concentration of PGD-S was highest in the epididymis-about 6- and 80-fold greater than that in the brain and testis, respectively. During maturation, PGD-S concentration increased steadily in the testis and epididymis; this is in contrast to the pattern of changes in the brain and liver, which showed a general trend of decline. Reverse transcription-polymerase chain reaction and Southern blotting were used to demonstrate the presence of PGD-S mRNA transcript in the testis and in Sertoli and germ cells. In the epididymis, the steady-state PGD-S mRNA level was highest in the caput, followed by the cauda and corpus. Orchiectomy induced a drastic reduction of PGD-S concentration in all three epididymal compartments. Administration of dihydrotestosterone (DHT) failed to restore the reduced epididymal PGD-S level except in the caput epididymis, where 4 days after DHT treatment the level of PGD-S was restored to about 50% of the pre-orchiectomized level; this suggests that the epididymal PGD-S level is not entirely regulated by androgen and that another yet to be identified testicular factor(s) is likely to be involved in its regulation. Germ cell-conditioned medium was also shown to stimulate PGD-S expression in the Sertoli cell. These results illustrate that PGD-S is an important molecule in testicular and epididymal function and that it is likely involved in spermatogenesis and sperm maturation. | lld:pubmed |
| pubmed-article:9746734 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9746734 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9746734 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9746734 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9746734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9746734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9746734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9746734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9746734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9746734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9746734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9746734 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9746734 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9746734 | pubmed:issn | 0006-3363 | lld:pubmed |
| pubmed-article:9746734 | pubmed:author | pubmed-author:SilvestriniBB | lld:pubmed |
| pubmed-article:9746734 | pubmed:author | pubmed-author:ChengC SCS | lld:pubmed |
| pubmed-article:9746734 | pubmed:author | pubmed-author:SunRR | lld:pubmed |
| pubmed-article:9746734 | pubmed:author | pubmed-author:ChengC YCY | lld:pubmed |
| pubmed-article:9746734 | pubmed:author | pubmed-author:LeoneM GMG | lld:pubmed |
| pubmed-article:9746734 | pubmed:author | pubmed-author:XieYY | lld:pubmed |
| pubmed-article:9746734 | pubmed:author | pubmed-author:ONGS TST | lld:pubmed |
| pubmed-article:9746734 | pubmed:author | pubmed-author:BraghiroliLL | lld:pubmed |
| pubmed-article:9746734 | pubmed:author | pubmed-author:GiacomelliSS | lld:pubmed |
| pubmed-article:9746734 | pubmed:author | pubmed-author:SorrentinoCC | lld:pubmed |
| pubmed-article:9746734 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9746734 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:9746734 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9746734 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9746734 | pubmed:pagination | 843-53 | lld:pubmed |
| pubmed-article:9746734 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9746734 | pubmed:meshHeading | pubmed-meshheading:9746734-... | lld:pubmed |
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| pubmed-article:9746734 | pubmed:meshHeading | pubmed-meshheading:9746734-... | lld:pubmed |
| pubmed-article:9746734 | pubmed:meshHeading | pubmed-meshheading:9746734-... | lld:pubmed |
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| pubmed-article:9746734 | pubmed:meshHeading | pubmed-meshheading:9746734-... | lld:pubmed |
| pubmed-article:9746734 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9746734 | pubmed:articleTitle | Rat prostaglandin D2 synthetase: its tissue distribution, changes during maturation, and regulation in the testis and epididymis. | lld:pubmed |
| pubmed-article:9746734 | pubmed:affiliation | The Population Council, New York, New York 10021, USA. | lld:pubmed |
| pubmed-article:9746734 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9746734 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9746734 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:25526 | entrezgene:pubmed | pubmed-article:9746734 | lld:entrezgene |
