Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
34
|
| pubmed:dateCreated |
1998-9-28
|
| pubmed:abstractText |
A new, radiation-free, conditioning protocol, containing the original Hungarian mitobronitol (DBM) (DBM/ cytosine arabinoside/cyclosphosphamide) has been applied to 36 chronic myeloid leukemia (CML) patients followed by bone marrow transplantation (BMT) from HLA identical sibling donors between 1990-1997. In spite of some prognostically disadvantageous factors (half of them were above 40 years, 10 out of 36 patients were in accelerated phase, the disease history was longer than 2 years in average) the overall survival (30/36) and the leukemia free survival rate (26/36) were in accordance with the best international results. Transplantation-related toxicity was remarkably reduced in comparison to bone marrow transplantation performed by total body irradiation/cyclophosphamide (TBI/Cy) or busulphan/cyclophosphamide (Bu/Cy) conditioning protocols. Acute graft versus host disease was present in lower percentage (9/36) and the number of serious cases was only 2/36. Chronic GVH disease, generally known to be associated with antileukemic effect (GVL), occurred in 25 of cases. Early haematological relapse among the 34 patients with functioning graft occurred in 6 patients which rate is slightly higher than reported after TBI/Cy or Bu/Cy conditioning treatment. There was no relapse among patients transplanted within one year post-diagnosis and patients having CML with accelerated phase. The leukemia free post-transplant period was in association with the chronic GVH disease and full chimeric state.
|
| pubmed:language |
hun
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0030-6002
|
| pubmed:author |
pubmed-author:BátaiAA,
pubmed-author:BarthFF,
pubmed-author:DénesRR,
pubmed-author:FöldiJJ,
pubmed-author:FeketeSS,
pubmed-author:GyódiEE,
pubmed-author:HofferII,
pubmed-author:JakabJJ,
pubmed-author:JakabKK,
pubmed-author:KelemenEE,
pubmed-author:LengyelLL,
pubmed-author:ManuelAA,
pubmed-author:MassziTT,
pubmed-author:PálócziKK,
pubmed-author:Páldi-HarisPP,
pubmed-author:PetrányiGG,
pubmed-author:RétiMM,
pubmed-author:ReményiPP,
pubmed-author:SiposAA,
pubmed-author:TörökJJ,
pubmed-author:TorbágyoEE,
pubmed-author:VáradiGG
|
| pubmed:issnType |
Print
|
| pubmed:day |
23
|
| pubmed:volume |
139
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2003-1; discussion 2011-2
|
| pubmed:dateRevised |
2009-10-21
|
| pubmed:meshHeading |
pubmed-meshheading:9745304-Adolescent,
pubmed-meshheading:9745304-Adult,
pubmed-meshheading:9745304-Bone Marrow Transplantation,
pubmed-meshheading:9745304-Clinical Protocols,
pubmed-meshheading:9745304-Female,
pubmed-meshheading:9745304-Graft vs Host Reaction,
pubmed-meshheading:9745304-Humans,
pubmed-meshheading:9745304-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:9745304-Male,
pubmed-meshheading:9745304-Middle Aged,
pubmed-meshheading:9745304-Mitobronitol
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
[A new radiation-free conditioning in bone marrow transplantation and dibromo-mannitol therapy in chronic myeloid leukemia].
|
| pubmed:affiliation |
Országos Hematológiai és Immunológiai Intézet Budapest.
|
| pubmed:publicationType |
Journal Article,
English Abstract,
Review
|