Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1998-10-9
pubmed:abstractText
We have recently reported that beta-ionone induces cytochrome P450 (P450) 2B1 in rats. Effects of beta-ionone on the expression of other P450 isozymes and NADPH-P450 reductase were further investigated in Sprague Dawley rats. Administration of beta-ionone subcutaneously 72 and 48 h before sacrificing the animals not only significantly induced the liver microsomal activities of P450-associated enzymes and NADPH-P450 reductase, but also clearly increased in the level of P450 1A1/2, P450 2C, and NADPH-P450 reductase proteins. The induction of P450 1A1/2 and 2C by beta-ionone was much greater in male than in female as measured by western immunoblotting. Reverse transcriptase-polymerase chain reactions showed that, in addition to P450 2B1 and 2B2 mRNAs, P450 1A2, 2C6 and NADPH-P450 reductase mRNAs were increased when beta-ionone was administered. Our previous and present results indicated that beta-ionone may induce several P450s and NADPH-P450 reductase by the accumulation of their corresponding mRNAs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases, http://linkedlifedata.com/resource/pubmed/chemical/Cyp2c6 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A2, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2B1, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/NADPH-Ferrihemoprotein Reductase, http://linkedlifedata.com/resource/pubmed/chemical/Norisoprenoids, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Steroid 21-Hydroxylase, http://linkedlifedata.com/resource/pubmed/chemical/Steroid Hydroxylases, http://linkedlifedata.com/resource/pubmed/chemical/Terpenes, http://linkedlifedata.com/resource/pubmed/chemical/beta-ionone, http://linkedlifedata.com/resource/pubmed/chemical/steroid 16-beta-hydroxylase
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0009-2797
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-107
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9744558-Animals, pubmed-meshheading:9744558-Aryl Hydrocarbon Hydroxylases, pubmed-meshheading:9744558-Cytochrome P-450 CYP1A2, pubmed-meshheading:9744558-Cytochrome P-450 CYP2B1, pubmed-meshheading:9744558-Cytochrome P-450 Enzyme System, pubmed-meshheading:9744558-Enzyme Induction, pubmed-meshheading:9744558-Female, pubmed-meshheading:9744558-Isoenzymes, pubmed-meshheading:9744558-Male, pubmed-meshheading:9744558-Microsomes, Liver, pubmed-meshheading:9744558-NADPH-Ferrihemoprotein Reductase, pubmed-meshheading:9744558-Norisoprenoids, pubmed-meshheading:9744558-RNA, Messenger, pubmed-meshheading:9744558-Rats, pubmed-meshheading:9744558-Rats, Sprague-Dawley, pubmed-meshheading:9744558-Sex Factors, pubmed-meshheading:9744558-Steroid 21-Hydroxylase, pubmed-meshheading:9744558-Steroid Hydroxylases, pubmed-meshheading:9744558-Terpenes
pubmed:year
1998
pubmed:articleTitle
Effects of beta-ionone on the expression of cytochrome P450s and NADPH-cytochrome P450 reductase in Sprague Dawley rats.
pubmed:affiliation
Toxicology Research Center, Korea Research Institute of Chemical Technology, Yusung, Taejon, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't