rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1998-10-9
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pubmed:abstractText |
We have recently reported that beta-ionone induces cytochrome P450 (P450) 2B1 in rats. Effects of beta-ionone on the expression of other P450 isozymes and NADPH-P450 reductase were further investigated in Sprague Dawley rats. Administration of beta-ionone subcutaneously 72 and 48 h before sacrificing the animals not only significantly induced the liver microsomal activities of P450-associated enzymes and NADPH-P450 reductase, but also clearly increased in the level of P450 1A1/2, P450 2C, and NADPH-P450 reductase proteins. The induction of P450 1A1/2 and 2C by beta-ionone was much greater in male than in female as measured by western immunoblotting. Reverse transcriptase-polymerase chain reactions showed that, in addition to P450 2B1 and 2B2 mRNAs, P450 1A2, 2C6 and NADPH-P450 reductase mRNAs were increased when beta-ionone was administered. Our previous and present results indicated that beta-ionone may induce several P450s and NADPH-P450 reductase by the accumulation of their corresponding mRNAs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyp2c6 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A2,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2B1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH-Ferrihemoprotein Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/Norisoprenoids,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Steroid 21-Hydroxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Steroid Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Terpenes,
http://linkedlifedata.com/resource/pubmed/chemical/beta-ionone,
http://linkedlifedata.com/resource/pubmed/chemical/steroid 16-beta-hydroxylase
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-2797
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-107
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9744558-Animals,
pubmed-meshheading:9744558-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:9744558-Cytochrome P-450 CYP1A2,
pubmed-meshheading:9744558-Cytochrome P-450 CYP2B1,
pubmed-meshheading:9744558-Cytochrome P-450 Enzyme System,
pubmed-meshheading:9744558-Enzyme Induction,
pubmed-meshheading:9744558-Female,
pubmed-meshheading:9744558-Isoenzymes,
pubmed-meshheading:9744558-Male,
pubmed-meshheading:9744558-Microsomes, Liver,
pubmed-meshheading:9744558-NADPH-Ferrihemoprotein Reductase,
pubmed-meshheading:9744558-Norisoprenoids,
pubmed-meshheading:9744558-RNA, Messenger,
pubmed-meshheading:9744558-Rats,
pubmed-meshheading:9744558-Rats, Sprague-Dawley,
pubmed-meshheading:9744558-Sex Factors,
pubmed-meshheading:9744558-Steroid 21-Hydroxylase,
pubmed-meshheading:9744558-Steroid Hydroxylases,
pubmed-meshheading:9744558-Terpenes
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pubmed:year |
1998
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pubmed:articleTitle |
Effects of beta-ionone on the expression of cytochrome P450s and NADPH-cytochrome P450 reductase in Sprague Dawley rats.
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pubmed:affiliation |
Toxicology Research Center, Korea Research Institute of Chemical Technology, Yusung, Taejon, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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