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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5384
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pubmed:dateCreated |
1998-10-9
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pubmed:abstractText |
The Fas death receptor can activate the Jun NH2-terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1, and overexpression of a kinase-deficient ASK1 mutant inhibited Fas- and Daxx-induced apoptosis and JNK activation. Fas activation induced Daxx to interact with ASK1, which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity. The Daxx-ASK1 connection completes a signaling pathway from a cell surface death receptor to kinase cascades that modulate nuclear transcription factors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DAXX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
281
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1860-3
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9743501-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:9743501-Alleles,
pubmed-meshheading:9743501-Amino Acid Sequence,
pubmed-meshheading:9743501-Animals,
pubmed-meshheading:9743501-Antigens, CD95,
pubmed-meshheading:9743501-Apoptosis,
pubmed-meshheading:9743501-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9743501-Carrier Proteins,
pubmed-meshheading:9743501-Cell Line,
pubmed-meshheading:9743501-Enzyme Activation,
pubmed-meshheading:9743501-Humans,
pubmed-meshheading:9743501-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:9743501-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:9743501-MAP Kinase Kinase Kinases,
pubmed-meshheading:9743501-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9743501-Molecular Sequence Data,
pubmed-meshheading:9743501-Nuclear Proteins,
pubmed-meshheading:9743501-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9743501-Recombinant Fusion Proteins,
pubmed-meshheading:9743501-Signal Transduction,
pubmed-meshheading:9743501-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.
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pubmed:affiliation |
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02138, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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