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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-12-10
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pubmed:abstractText |
The bactericidal efficacy of aminoglycosides is directly related to peak serum concentration (Cmax), particularly the first one. Transitory high concentrations of aminoglycosides do not result in such a high drug uptake by renal and cochlear tissues because of the saturation of cell binding sites. These observations have led to the concept that less frequent administration of relatively larger doses of aminoglycosides would be of interest in treating infectious diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-3126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
351-62
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9742264-Aminoglycosides,
pubmed-meshheading:9742264-Creatinine,
pubmed-meshheading:9742264-Dose-Response Relationship, Drug,
pubmed-meshheading:9742264-Drug Administration Schedule,
pubmed-meshheading:9742264-Evaluation Studies as Topic,
pubmed-meshheading:9742264-Evoked Potentials, Auditory, Brain Stem,
pubmed-meshheading:9742264-Female,
pubmed-meshheading:9742264-Gestational Age,
pubmed-meshheading:9742264-Humans,
pubmed-meshheading:9742264-Infant, Newborn,
pubmed-meshheading:9742264-Infant, Newborn, Diseases,
pubmed-meshheading:9742264-Infection,
pubmed-meshheading:9742264-Intensive Care Units, Neonatal,
pubmed-meshheading:9742264-Kidney,
pubmed-meshheading:9742264-Male,
pubmed-meshheading:9742264-Medical Records,
pubmed-meshheading:9742264-Neonatology,
pubmed-meshheading:9742264-Osmolar Concentration,
pubmed-meshheading:9742264-Prospective Studies
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pubmed:year |
1998
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pubmed:articleTitle |
Adaptation in neonatology of the once-daily concept of aminoglycoside administration: evaluation of a dosing chart for amikacin in an intensive care unit.
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pubmed:affiliation |
Neonatal Intensive Care Unit, St Vincent's Clinic; Department of Pediatrics, Children's Hospital, St Joseph's Clinic, Rocourt, Belgium.
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pubmed:publicationType |
Journal Article
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