Linked Life Data

9741360

Source:http://linkedlifedata.com/resource/pubmed/id/9741360

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-10-7
pubmed:abstractText
Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method and compared between the resistant and susceptible mice. In a fatal disease, the lesions in both animal hosts began with focal abscesses within the first three days post infection. Mononuclear cell infiltration started by day 4 and transformed the lesions into granulomata. Well-formed granulomata were evident by day 7 and persisted in sublethally infected resistant mice. Massive bacterial proliferation and extensive tissue degeneration marked the terminal stage of a lethal challenge. There were no distinguishable features that would identify the tissue response to infection in a resistant host from a susceptible one, except that the lesions in the sublethally infected resistant mice advanced slower and were discrete and self-limiting.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0959-9673
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-92
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Comparative histopathology in mouse typhoid among genetically diverse mice.
pubmed:affiliation
Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0678, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.