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pubmed-article:9740799pubmed:abstractTextCyclins and cyclin-dependent kinases induce and coordinate the events of the cell cycle, although the mechanisms by which they do so remain largely unknown. In budding yeast, a pathway used by the Clb2 cyclin to control bud growth during mitosis provides a good model system in which to understand how cyclin-dependent kinases control cell-cycle events. In this pathway, Clb2 initiates a series of events that lead to the mitosis-specific activation of the Gin4 protein kinase. A protein called Nap1 is required in vivo for the activation of Gin4, and is able to bind to both Gin4 and Clb2. We have used a simple genetic screen to identify additional proteins that function in this pathway.lld:pubmed
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pubmed-article:9740799pubmed:articleTitleControl of mitotic events by the Cdc42 GTPase, the Clb2 cyclin and a member of the PAK kinase family.lld:pubmed
pubmed-article:9740799pubmed:affiliationSinsheimer Laboratories, Department of Biology, University of California, Santa Cruz 95064, USA.lld:pubmed
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