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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1998-12-7
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pubmed:abstractText |
Cyclins and cyclin-dependent kinases induce and coordinate the events of the cell cycle, although the mechanisms by which they do so remain largely unknown. In budding yeast, a pathway used by the Clb2 cyclin to control bud growth during mitosis provides a good model system in which to understand how cyclin-dependent kinases control cell-cycle events. In this pathway, Clb2 initiates a series of events that lead to the mitosis-specific activation of the Gin4 protein kinase. A protein called Nap1 is required in vivo for the activation of Gin4, and is able to bind to both Gin4 and Clb2. We have used a simple genetic screen to identify additional proteins that function in this pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CLA4 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/CLB2 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin B,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GIN4 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/cdc42 GTP-Binding Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
991-1000
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9740799-Cell Cycle,
pubmed-meshheading:9740799-Cell Cycle Proteins,
pubmed-meshheading:9740799-Cloning, Molecular,
pubmed-meshheading:9740799-Cyclin B,
pubmed-meshheading:9740799-Cyclin-Dependent Kinases,
pubmed-meshheading:9740799-Cyclins,
pubmed-meshheading:9740799-Fungal Proteins,
pubmed-meshheading:9740799-GTP-Binding Proteins,
pubmed-meshheading:9740799-Gene Deletion,
pubmed-meshheading:9740799-Genetic Complementation Test,
pubmed-meshheading:9740799-Mitosis,
pubmed-meshheading:9740799-Mutagenesis,
pubmed-meshheading:9740799-Phosphorylation,
pubmed-meshheading:9740799-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9740799-Recombinant Proteins,
pubmed-meshheading:9740799-Saccharomyces cerevisiae,
pubmed-meshheading:9740799-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:9740799-cdc42 GTP-Binding Protein, Saccharomyces cerevisiae
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pubmed:year |
1998
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pubmed:articleTitle |
Control of mitotic events by the Cdc42 GTPase, the Clb2 cyclin and a member of the PAK kinase family.
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pubmed:affiliation |
Sinsheimer Laboratories, Department of Biology, University of California, Santa Cruz 95064, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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