Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1998-10-15
|
| pubmed:abstractText |
Damage of large arteries is a major contributory factor to the high pulse pressure observed in patients with end-stage renal disease. Whether incremental modulus of elasticity (Einc), a classic marker of arterial stiffness, can predict cardiovascular mortality has never been investigated. A cohort of 79 patients with end-stage renal disease undergoing hemodialysis was studied between September 1995 and January 1998. Mean age at entry was 58+/-15 years. The duration of follow-up was 25+/-7 months, during which 10 cardiovascular and 8 noncardiovascular fatal events occurred. At entry, carotid Einc was calculated from measurements of diameter, thickness (echo-tracking technique), and pulse pressure (tonometry). Based on Cox analyses, 2 dominant factors emerged as predictors of all-cause and cardiovascular mortality: increased Einc and decreased diastolic blood pressure. Lipid abnormalities and the presence of previous cardiovascular events interfered to a smaller extent. After adjustment for confounding variables, the odds ratio for Einc >/=1 kPa-3 was 9.2 (95% confidence interval, 2.4 to 35.0) for all-cause mortality. These results provide the first direct evidence that in patients with end-stage renal disease undergoing hemodialysis, arterial alterations, as determined from carotid Einc, are strong independent predictors of all-cause and cardiovascular mortality.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0194-911X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
570-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9740628-Aged,
pubmed-meshheading:9740628-Cardiovascular Diseases,
pubmed-meshheading:9740628-Carotid Arteries,
pubmed-meshheading:9740628-Confounding Factors (Epidemiology),
pubmed-meshheading:9740628-Diabetes Mellitus, Type 1,
pubmed-meshheading:9740628-Elasticity,
pubmed-meshheading:9740628-Female,
pubmed-meshheading:9740628-Humans,
pubmed-meshheading:9740628-Kidney Failure, Chronic,
pubmed-meshheading:9740628-Male,
pubmed-meshheading:9740628-Middle Aged,
pubmed-meshheading:9740628-Predictive Value of Tests,
pubmed-meshheading:9740628-Prognosis,
pubmed-meshheading:9740628-Prospective Studies,
pubmed-meshheading:9740628-Questionnaires,
pubmed-meshheading:9740628-Regression Analysis,
pubmed-meshheading:9740628-Renal Dialysis,
pubmed-meshheading:9740628-Survival Analysis
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease.
|
| pubmed:affiliation |
From the Service de Médecine Interne, Hôpital Broussais, Paris, and Service d'Hémodialyse, Hôpital F.H. Manhès, Fleury-Mérogis, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|