Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-10-13
pubmed:abstractText
We have generated transgenic nonobese diabetic (NOD) mice expressing dominant negative mutant IFN-gamma receptors on pancreatic beta cells to investigate whether the direct effects of IFN-gamma on beta cells contribute to autoimmune diabetes. We have also quantitated by flow cytometry the rise in class I MHC on beta cells of NOD mice with increasing age and degree of islet inflammatory infiltrate. Class I MHC expression increases gradually with age in wild-type NOD mice; however, no such increase is observed in the transgenic beta cells. The transgenic mice develop diabetes at a similar rate to that of wild-type animals. This study dissociates class I MHC upregulation from progression to diabetes, shows that the rise in class I MHC is due to local IFN-gamma action, and eliminates beta cells as the targets of IFN-gamma in autoimmune diabetes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-1376354, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-1385478, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-1647994, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-1674689, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-1722764, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-1899431, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-1901764, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-1901765, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-1909135, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-2771659, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-2862019, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-3046971, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-3109087, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-3292330, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-3353714, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-388422, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-3915782, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-7135466, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-7530759, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-7533326, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-7540572, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-7584155, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-7722337, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-7781592, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-7789642, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-7819154, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-7869054, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-7913115, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8197455, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8227346, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8258349, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8304235, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8314024, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8314025, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8387525, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8483949, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8496610, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8510533, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8549863, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8600386, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8635653, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8635658, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8858209, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8871671, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8932996, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-8940385, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-9053453, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-9064352, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-9352596, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739059-9391115
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1249-57
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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