Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-10-13
pubmed:abstractText
Winged helix transcription factors play important roles in cellular differentiation and cell-specific gene expression. To define the role of the winged helix factor hepatocyte nuclear factor/forkhead homologue (HFH)-4, a targeted mutation was created in the mouse hfh-4 gene. No expression of HFH-4 was detected in hfh-4(-)/- mice by RNA blot analysis, in situ hybridization, or RT-PCR. hfh-4(-)/- mice were noted to have abnormalities of organ situs consistent with random determination of left-right asymmetry. In addition, a complete absence of cilia was noted in hfh-4(-)/- mice. The hfh-4 gene is thus essential for nonrandom determination of left-right asymmetry and development of ciliated cells. Homozygous mutant mice also exhibited prenatal and postnatal growth failure, perinatal lethality and, in some cases, hydrocephalus. RT-PCR revealed an absence of left-right dynein (lrd) expression in the embryonic lungs of hfh-4(-)/- mice, suggesting that HFH-4 may act by regulating expression of members of the dynein family of genes. The abnormalities in ciliary development and organ situs in hfh-4(-)/- mice are similar to those observed in human congenital syndromes such as Kartagener syndrome. Targeted mutation of hfh-4 thus provides a model for elucidating the mechanisms regulating ciliary development and determination of left-right asymmetry.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-1021593, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-1409605, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-1456301, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-1566856, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-1576603, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-1638728, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-1802646, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-1959204, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-1992761, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-2063904, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-2209459, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-2225060, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-6512242, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-7524494, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-7532283, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-7683413, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-7753791, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-7881129, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-7888180, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-8298651, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-8332212, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-8378314, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-8610011, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-8610012, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-8610013, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-8645568, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-8817449, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-8901057, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-8943227, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-9096351, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-9348041, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-9353118, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-9353126, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-9367675, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-9421811, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-9530170, http://linkedlifedata.com/resource/pubmed/commentcorrection/9739041-9572118
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1077-82
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9739041-Testis, pubmed-meshheading:9739041-Animals, pubmed-meshheading:9739041-Mice, pubmed-meshheading:9739041-Lung, pubmed-meshheading:9739041-Growth, pubmed-meshheading:9739041-Oviducts, pubmed-meshheading:9739041-Choroid Plexus, pubmed-meshheading:9739041-Mutation, pubmed-meshheading:9739041-Cilia, pubmed-meshheading:9739041-Female, pubmed-meshheading:9739041-Male, pubmed-meshheading:9739041-Abnormalities, Multiple, pubmed-meshheading:9739041-Kartagener Syndrome, pubmed-meshheading:9739041-Nuclear Proteins, pubmed-meshheading:9739041-Phosphoproteins, pubmed-meshheading:9739041-Sequence Homology, Amino Acid, pubmed-meshheading:9739041-Body Patterning, pubmed-meshheading:9739041-DNA-Binding Proteins, pubmed-meshheading:9739041-Transcription Factors, pubmed-meshheading:9739041-Dyneins, pubmed-meshheading:9739041-Forkhead Transcription Factors
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