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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-9-25
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001090,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001091,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001092,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001093,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001094,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001095,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001096,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001097,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001098,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001099,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001100,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001101,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001102,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AB001103
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pubmed:abstractText |
We have previously reported frequent allelic loss in chromosome bands 16q24.1-q24.2 in human lung cancer. Since the H-cadherin (CDH13) gene has been isolated and mapped to this common region of allelic loss, we have investigated this gene in human lung cancer. The reverse transcription/polymerase chain reaction technique has revealed the loss of expression in four (57%) of seven lung cancer cell lines. To study the CDH13 gene further, we have analyzed deletions, genetic alterations, and methylation status at the 5' region of this gene. Three (75%) of four cell lines that have lost expression show a deletion of the CDH13 locus accompanied by hypermethylation of the remaining allele. Moreover, hypermethylation has been observed in nine (45%) of 20 primary lung cancers. These results suggest that a combination of deletion and hypermethylation causes inactivation of the CDH13 gene in a considerable number of human lung cancers.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0340-6717
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-101
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9737784-Base Sequence,
pubmed-meshheading:9737784-Cadherins,
pubmed-meshheading:9737784-Chromosome Deletion,
pubmed-meshheading:9737784-Chromosome Mapping,
pubmed-meshheading:9737784-Chromosomes, Human, Pair 16,
pubmed-meshheading:9737784-Cloning, Molecular,
pubmed-meshheading:9737784-Cosmids,
pubmed-meshheading:9737784-DNA Methylation,
pubmed-meshheading:9737784-Exons,
pubmed-meshheading:9737784-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:9737784-Genes, Tumor Suppressor,
pubmed-meshheading:9737784-Humans,
pubmed-meshheading:9737784-Lung Neoplasms,
pubmed-meshheading:9737784-Molecular Sequence Data,
pubmed-meshheading:9737784-Promoter Regions, Genetic
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pubmed:year |
1998
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pubmed:articleTitle |
The H-cadherin (CDH13) gene is inactivated in human lung cancer.
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pubmed:affiliation |
Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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