rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1998-9-25
|
pubmed:abstractText |
We report the occurrence of acute heparin-induced thrombocytopenia in a patient with anaphylaxis that began immediately after an intravenous bolus dose of unfractionated heparin. This case report is the first to document the concurrence of these 2 reactions to heparin. An abrupt fall in platelet count was documented immediately after the anaphylactic response. Study results for antibodies characteristic of heparin-induced thrombocytopenia were positive in 2 assays: serotonin release assay and heparin platelet factor 4 enzyme-linked immunosorbent assay. The patient's antibody was exclusively immunoglobulin G. Any explanation for the relationship between the antibody response observed and the histamine release remains speculative.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0741-5214
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
28
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
561-5
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:9737470-Acute Disease,
pubmed-meshheading:9737470-Anaphylaxis,
pubmed-meshheading:9737470-Antibodies,
pubmed-meshheading:9737470-Antigen-Antibody Complex,
pubmed-meshheading:9737470-Blood Platelets,
pubmed-meshheading:9737470-Heparin,
pubmed-meshheading:9737470-Humans,
pubmed-meshheading:9737470-Immunoglobulin G,
pubmed-meshheading:9737470-Male,
pubmed-meshheading:9737470-Middle Aged,
pubmed-meshheading:9737470-Platelet Count,
pubmed-meshheading:9737470-Platelet Factor 4,
pubmed-meshheading:9737470-Thrombocytopenia
|
pubmed:year |
1998
|
pubmed:articleTitle |
Concurrence of anaphylaxis and acute heparin-induced thrombocytopenia in a patient with heparin-induced antibodies.
|
pubmed:affiliation |
Department of Surgery, Tulane University School of Medicine, New Orleans, LA, USA.
|
pubmed:publicationType |
Journal Article,
Case Reports
|