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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1998-10-2
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pubmed:abstractText |
In mammalian myelinated nerves, the internodal axon that is normally concealed by the myelin sheath expresses a rich repertoire of K channel subtypes thought to be important in modulating action potential propagation. The function of myelin-covered K channels at transition zones, however, has remained unexplored. Here we show that deleting the voltage-sensitive potassium channel Kv1.1 from mice confers a marked temperature-sensitivity to neuromuscular transmission in postnatal day 14 (P14)-P21 mice. Using immunofluorescence and electrophysiology, we examined contributions of four regions of the peripheral nervous system to the mutant phenotype: the nerve trunk, the myelinated segment preceding the terminal, the presynaptic terminal membrane itself, and the muscle. We conclude that the temperature-sensitive neuromuscular transmission is accounted for solely by a deficiency in Kv1.1 normally concealed in the myelinated segments just preceding the terminal. This paper demonstrates that under certain situations of physiological stress, the functional role of myelin-covered K channels is dramatically enhanced as the transition zone at the neuromuscular junction is approached.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Batrachotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Curare,
http://linkedlifedata.com/resource/pubmed/chemical/Elapid Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/Kcna1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Kv1.1 Potassium Channel,
http://linkedlifedata.com/resource/pubmed/chemical/Lidocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Neostigmine,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotinic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Parasympathomimetics,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Voltage-Gated,
http://linkedlifedata.com/resource/pubmed/chemical/batrachotoxinin A 20-alpha-benzoate,
http://linkedlifedata.com/resource/pubmed/chemical/dendrotoxin
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0270-6474
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7200-15
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9736643-Age Factors,
pubmed-meshheading:9736643-Anesthetics, Local,
pubmed-meshheading:9736643-Animals,
pubmed-meshheading:9736643-Batrachotoxins,
pubmed-meshheading:9736643-Behavior, Animal,
pubmed-meshheading:9736643-Cold Temperature,
pubmed-meshheading:9736643-Curare,
pubmed-meshheading:9736643-Elapid Venoms,
pubmed-meshheading:9736643-Electric Stimulation,
pubmed-meshheading:9736643-Electroencephalography,
pubmed-meshheading:9736643-Electrophysiology,
pubmed-meshheading:9736643-Female,
pubmed-meshheading:9736643-Kv1.1 Potassium Channel,
pubmed-meshheading:9736643-Lidocaine,
pubmed-meshheading:9736643-Male,
pubmed-meshheading:9736643-Mice,
pubmed-meshheading:9736643-Mice, Knockout,
pubmed-meshheading:9736643-Motor Neurons,
pubmed-meshheading:9736643-Muscle, Skeletal,
pubmed-meshheading:9736643-Myelin Sheath,
pubmed-meshheading:9736643-Neostigmine,
pubmed-meshheading:9736643-Neuromuscular Junction,
pubmed-meshheading:9736643-Neurotoxins,
pubmed-meshheading:9736643-Nicotinic Antagonists,
pubmed-meshheading:9736643-Parasympathomimetics,
pubmed-meshheading:9736643-Phrenic Nerve,
pubmed-meshheading:9736643-Potassium Channels,
pubmed-meshheading:9736643-Potassium Channels, Voltage-Gated,
pubmed-meshheading:9736643-Presynaptic Terminals,
pubmed-meshheading:9736643-Sciatic Nerve,
pubmed-meshheading:9736643-Synaptic Transmission,
pubmed-meshheading:9736643-Temperature
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pubmed:year |
1998
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pubmed:articleTitle |
Temperature-sensitive neuromuscular transmission in Kv1.1 null mice: role of potassium channels under the myelin sheath in young nerves.
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pubmed:affiliation |
Department of Physiology, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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