|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0017262,
umls-concept:C0185117,
umls-concept:C0286983,
umls-concept:C0301630,
umls-concept:C0812444,
umls-concept:C1413246,
umls-concept:C1516213,
umls-concept:C1705784,
umls-concept:C1707520,
umls-concept:C2825055,
umls-concept:C2911684
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1998-9-24
|
|
pubmed:abstractText |
MRP-1/CD9, KAI1/CD82, and ME491/CD63, have been reported to be associated with the metastatic potential of solid tumors. The aim of this study was to determine whether their expression in tumor tissues is a useful indicator for prognosis in breast cancer patients. We studied 109 breast cancer patients who underwent surgery. Quantitative reverse transcription-polymerase chain reaction analysis was performed to evaluate the expression of these genes. The results were confirmed with immunohistochemistry. All of the carcinomas were ME491/CD63 positive. Thirty-six tumors were MRP-1/CD9 negative. The disease-free survival rate and the 5-year survival rate of patients with MRP-1/CD9-negative tumors were both significantly lower than that in patients with MRP-1/ CD9-positive tumors (P = 0.0005 and P = 0.0380, respectively). Sixty-five tumors were KAI1/CD82 negative. The disease-free survival rate of patients with KAI1/CD82-negative tumors was significantly lower than that of patients with KAI1/CD82-positive tumors (P = 0.0065). Cox regression analysis demonstrated that MRP-1/CD9 status (P = 0.0016) and KAI1/CD82 status (P = 0.0234) were useful indicators for the disease-free survival of breast cancer patients. The disease-free survival rate and 5-year survival rate of patients with either MRP-1/CD9-negative or KAI1/CD82-negative tumors were both significantly lower than patients who were positive for both genes (P = 0.0003 and P = 0.0292, respectively). The expression of MRP-1/CD9 and KAI1/CD82 genes are useful indicators of a poor prognosis in breast cancer patients.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-1378828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-1401919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-1695320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-1720807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-1842498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-2258620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-2466944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-2994062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-3365686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-3524805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-5910392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-7531445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-7664290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-7665237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-7754374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-7794075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-7915096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-7954259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8119731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8423624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8478605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8521390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8577720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8620488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8640807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8672529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8688552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8757325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8813131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8814449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8816400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-8921952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-9058814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-9205061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-9496911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9736046-9570365
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD82,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD9,
http://linkedlifedata.com/resource/pubmed/chemical/CD82 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CD9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0002-9440
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
153
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
973-83
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:9736046-Aged,
pubmed-meshheading:9736046-Antigens, CD,
pubmed-meshheading:9736046-Antigens, CD82,
pubmed-meshheading:9736046-Antigens, CD9,
pubmed-meshheading:9736046-Breast Neoplasms,
pubmed-meshheading:9736046-Carcinoma, Ductal, Breast,
pubmed-meshheading:9736046-DNA Primers,
pubmed-meshheading:9736046-Disease-Free Survival,
pubmed-meshheading:9736046-Female,
pubmed-meshheading:9736046-Gene Expression,
pubmed-meshheading:9736046-Humans,
pubmed-meshheading:9736046-Immunoenzyme Techniques,
pubmed-meshheading:9736046-Membrane Glycoproteins,
pubmed-meshheading:9736046-Middle Aged,
pubmed-meshheading:9736046-Neoplasm Recurrence, Local,
pubmed-meshheading:9736046-Polymerase Chain Reaction,
pubmed-meshheading:9736046-Proto-Oncogene Proteins,
pubmed-meshheading:9736046-Survival Analysis,
pubmed-meshheading:9736046-Tumor Markers, Biological
|
|
pubmed:year |
1998
|
