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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-9-18
|
| pubmed:abstractText |
Recruitment of blood monocytes into the arterial subendothelium is one of the earliest steps in atherogenesis. Monocyte chemoattractant protein-1 (MCP-1), a CC chemokine, is one likely signal involved in this process. To test MCP-1's role in atherogenesis, low density lipoprotein (LDL) receptor-deficient mice were made genetically deficient for MCP-1 and fed a high cholesterol diet. Despite having the same amount of total and fractionated serum cholesterol as LDL receptor-deficient mice with wild-type MCP-1 alleles, LDL receptor/MCP-1-deficient mice had 83% less lipid deposition throughout their aortas. Consistent with MCP-1 's monocyte chemoattractant properties, compound-deficient mice also had fewer macrophages in their aortic walls. Thus, MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1097-2765
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
275-81
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9734366-Animals,
pubmed-meshheading:9734366-Aorta,
pubmed-meshheading:9734366-Arteriosclerosis,
pubmed-meshheading:9734366-Base Sequence,
pubmed-meshheading:9734366-Cell Movement,
pubmed-meshheading:9734366-Chemokine CCL2,
pubmed-meshheading:9734366-DNA Primers,
pubmed-meshheading:9734366-Diet, Atherogenic,
pubmed-meshheading:9734366-Female,
pubmed-meshheading:9734366-Lipid Metabolism,
pubmed-meshheading:9734366-Lipids,
pubmed-meshheading:9734366-Macrophages,
pubmed-meshheading:9734366-Male,
pubmed-meshheading:9734366-Mice,
pubmed-meshheading:9734366-Mice, Inbred C57BL,
pubmed-meshheading:9734366-Mice, Knockout,
pubmed-meshheading:9734366-Monocytes,
pubmed-meshheading:9734366-Polymerase Chain Reaction,
pubmed-meshheading:9734366-Receptors, LDL
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice.
|
| pubmed:affiliation |
Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|