|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5383
|
|
pubmed:dateCreated |
1998-10-7
|
|
pubmed:abstractText |
Hypertrophic cardiomyopathy (HCM) is an inherited form of heart disease that affects 1 in 500 individuals. Here it is shown that calcineurin, a calcium-regulated phosphatase, plays a critical role in the pathogenesis of HCM. Administration of the calcineurin inhibitors cyclosporin and FK506 prevented disease in mice that were genetically predisposed to develop HCM as a result of aberrant expression of tropomodulin, myosin light chain-2, or fetal beta-tropomyosin in the heart. Cyclosporin had a similar effect in a rat model of pressure-overload hypertrophy. These results suggest that calcineurin inhibitors merit investigation as potential therapeutics for certain forms of human heart disease.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcineurin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cardiac Myosins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Light Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus,
http://linkedlifedata.com/resource/pubmed/chemical/Tmod1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tmod1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Tropomodulin,
http://linkedlifedata.com/resource/pubmed/chemical/Tropomyosin,
http://linkedlifedata.com/resource/pubmed/chemical/myosin light chain 2
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
11
|
|
pubmed:volume |
281
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1690-3
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:9733519-Animals,
pubmed-meshheading:9733519-Calcineurin,
pubmed-meshheading:9733519-Calcium,
pubmed-meshheading:9733519-Cardiac Myosins,
pubmed-meshheading:9733519-Cardiomegaly,
pubmed-meshheading:9733519-Cardiomyopathy, Dilated,
pubmed-meshheading:9733519-Cardiomyopathy, Hypertrophic,
pubmed-meshheading:9733519-Carrier Proteins,
pubmed-meshheading:9733519-Cyclosporine,
pubmed-meshheading:9733519-Female,
pubmed-meshheading:9733519-Mice,
pubmed-meshheading:9733519-Mice, Transgenic,
pubmed-meshheading:9733519-Microfilament Proteins,
pubmed-meshheading:9733519-Models, Cardiovascular,
pubmed-meshheading:9733519-Myocardium,
pubmed-meshheading:9733519-Myosin Light Chains,
pubmed-meshheading:9733519-Rats,
pubmed-meshheading:9733519-Signal Transduction,
pubmed-meshheading:9733519-Tacrolimus,
pubmed-meshheading:9733519-Tropomodulin,
pubmed-meshheading:9733519-Tropomyosin
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Prevention of cardiac hypertrophy in mice by calcineurin inhibition.
|
|
pubmed:affiliation |
Division of Molecular Cardiovascular Biology, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
