| pubmed-article:9733518 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9733518 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:9733518 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:9733518 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:9733518 | lifeskim:mentions | umls-concept:C1334960 | lld:lifeskim |
| pubmed-article:9733518 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:9733518 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:9733518 | lifeskim:mentions | umls-concept:C1555903 | lld:lifeskim |
| pubmed-article:9733518 | lifeskim:mentions | umls-concept:C0243067 | lld:lifeskim |
| pubmed-article:9733518 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:9733518 | pubmed:issue | 5383 | lld:pubmed |
| pubmed-article:9733518 | pubmed:dateCreated | 1998-10-7 | lld:pubmed |
| pubmed-article:9733518 | pubmed:abstractText | Neuropeptides serve as important signaling molecules in the nervous system. The FMRFamide (Phe-Met-Arg-Phe-amide)-related neuropeptide gene family in the nematode Caenorhabditis elegans is composed of at least 18 genes that may encode 53 distinct FMRFamide-related peptides. Disruption of one of these genes, flp-1, causes numerous behavioral defects, including uncoordination, hyperactivity, and insensitivity to high osmolarity. Conversely, overexpression of flp-1 results in the reciprocal phenotypes. On the basis of epistasis analysis, flp-1 gene products appear to signal upstream of a G protein-coupled second messenger system. These results demonstrate that varying the levels of FLP-1 neuropeptides can profoundly affect behavior and that members of this large neuropeptide gene family are not functionally redundant in C. elegans. | lld:pubmed |
| pubmed-article:9733518 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9733518 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9733518 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9733518 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9733518 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9733518 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:9733518 | pubmed:author | pubmed-author:MAJJ | lld:pubmed |
| pubmed-article:9733518 | pubmed:author | pubmed-author:NelsonL SLS | lld:pubmed |
| pubmed-article:9733518 | pubmed:author | pubmed-author:RosoffM LML | lld:pubmed |
| pubmed-article:9733518 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9733518 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:9733518 | pubmed:volume | 281 | lld:pubmed |
| pubmed-article:9733518 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9733518 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9733518 | pubmed:pagination | 1686-90 | lld:pubmed |
| pubmed-article:9733518 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9733518 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9733518 | pubmed:articleTitle | Disruption of a neuropeptide gene, flp-1, causes multiple behavioral defects in Caenorhabditis elegans. | lld:pubmed |
| pubmed-article:9733518 | pubmed:affiliation | Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA. | lld:pubmed |
| pubmed-article:9733518 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9733518 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9733518 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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