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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1998-10-8
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pubmed:abstractText |
The anticancer drug paclitaxel (Taxol) has been converted to a large number of 2-debenzoyl-2-aroyl derivatives by three different methods. The bioactivities of the resulting analogues were determined in both tubulin polymerization and cytotoxicity assays, and several analogues with enhanced activity as compared with paclitaxel were discovered. Correlation of cytotoxicity in three cell lines with tubulin polymerization activity showed reasonable agreement. Among the cell lines examined, the closest correlation with antitubulin activity was observed with a human ovarian carcinoma cell line.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:ChaudharyA GAG,
pubmed-author:ChordiaM DMD,
pubmed-author:FairchildC RCR,
pubmed-author:GharpureMM,
pubmed-author:GiannakakouPP,
pubmed-author:GunatilakaA AAA,
pubmed-author:HamelEE,
pubmed-author:HiggsP IPI,
pubmed-author:JagtapP GPG,
pubmed-author:JiangY QYQ,
pubmed-author:JohnstonK AKA,
pubmed-author:KingstonD GDG,
pubmed-author:LinC MCM,
pubmed-author:LongB HBH,
pubmed-author:RimoldiJ MJM,
pubmed-author:SamalaLL
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3715-26
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9733497-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:9733497-Biopolymers,
pubmed-meshheading:9733497-Catalysis,
pubmed-meshheading:9733497-Cell Division,
pubmed-meshheading:9733497-Drug Screening Assays, Antitumor,
pubmed-meshheading:9733497-Humans,
pubmed-meshheading:9733497-Paclitaxel,
pubmed-meshheading:9733497-Polyethylene Glycols,
pubmed-meshheading:9733497-Structure-Activity Relationship,
pubmed-meshheading:9733497-Tubulin,
pubmed-meshheading:9733497-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).
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pubmed:affiliation |
Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey 05843, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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