| pubmed-article:9733362 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9733362 | lifeskim:mentions | umls-concept:C0014563 | lld:lifeskim |
| pubmed-article:9733362 | lifeskim:mentions | umls-concept:C1882561 | lld:lifeskim |
| pubmed-article:9733362 | lifeskim:mentions | umls-concept:C0012471 | lld:lifeskim |
| pubmed-article:9733362 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:9733362 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:9733362 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9733362 | pubmed:dateCreated | 1998-11-23 | lld:pubmed |
| pubmed-article:9733362 | pubmed:abstractText | 8-epi prostaglandin F2alpha(8-epi PGF2alpha) contracted rat thoracic aorta rings in a concentration-dependent manner in the presence or absence of functional endothelium [median effective concentration (EC50) values, 455+/-52 and 268+/-34 nM, respectively; Student's t test; p=0.006]. U46619 was a more potent agonist with or without functional endothelium (EC50 values, 6.8+/-1.6 and 4.5+/-1.0 nM, respectively). SQ29548 [a thromboxane (TP)-receptor antagonist] inhibited contractions to both 8-epi PGF2alpha and U46619 in a competitive manner, with mean pA2 values of 8.3 and 7.9, respectively. 8-Epi PGF2alpha had a further contractile effect in vessels that had been contracted with noradrenaline and had been shown to possess a functional endothelium. Inhibition of thromboxane synthesis with OKY-046 or blockade of endothelin receptors with bosentan had no effect on responses to 8-epi PGF2alpha or U46619. Preincubation with 8-epi PGF2alpha or noradrenaline shifted the concentration-response curves to U46619 upward at low concentrations of U46619 with no significant change in EC50 values or maximal responses. Reduction of TP-receptor number in rat aorta with dithiothreitol caused a concentration-dependent inhibition of responses to both U46619 and 8-epi PGF2alpha, with no effect on maximal responses and or on the responses to U46619 after the preincubation with 8-epi PGF2alpha. These results indicate that 8-epi PGF2alpha is a potent vasoconstrictor in the rat aorta and are suggestive of an action of 8-epi PGF2alpha at the TP receptor. | lld:pubmed |
| pubmed-article:9733362 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9733362 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9733362 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9733362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9733362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9733362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9733362 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9733362 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9733362 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9733362 | pubmed:issn | 0160-2446 | lld:pubmed |
| pubmed-article:9733362 | pubmed:author | pubmed-author:TippinsJ RJR | lld:pubmed |
| pubmed-article:9733362 | pubmed:author | pubmed-author:KromerB MBM | lld:pubmed |
| pubmed-article:9733362 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9733362 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:9733362 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9733362 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9733362 | pubmed:pagination | 471-8 | lld:pubmed |
| pubmed-article:9733362 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9733362 | pubmed:meshHeading | pubmed-meshheading:9733362-... | lld:pubmed |
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| pubmed-article:9733362 | pubmed:meshHeading | pubmed-meshheading:9733362-... | lld:pubmed |
| pubmed-article:9733362 | pubmed:meshHeading | pubmed-meshheading:9733362-... | lld:pubmed |
| pubmed-article:9733362 | pubmed:meshHeading | pubmed-meshheading:9733362-... | lld:pubmed |
| pubmed-article:9733362 | pubmed:meshHeading | pubmed-meshheading:9733362-... | lld:pubmed |
| pubmed-article:9733362 | pubmed:meshHeading | pubmed-meshheading:9733362-... | lld:pubmed |
| pubmed-article:9733362 | pubmed:meshHeading | pubmed-meshheading:9733362-... | lld:pubmed |
| pubmed-article:9733362 | pubmed:meshHeading | pubmed-meshheading:9733362-... | lld:pubmed |
| pubmed-article:9733362 | pubmed:meshHeading | pubmed-meshheading:9733362-... | lld:pubmed |
| pubmed-article:9733362 | pubmed:meshHeading | pubmed-meshheading:9733362-... | lld:pubmed |
| pubmed-article:9733362 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9733362 | pubmed:articleTitle | Actions of 8 epi prostaglandin F2alpha on isolated rat aorta. | lld:pubmed |
| pubmed-article:9733362 | pubmed:affiliation | Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, England. | lld:pubmed |
| pubmed-article:9733362 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9733362 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9733362 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9733362 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9733362 | lld:pubmed |
