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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
17
|
| pubmed:dateCreated |
1998-9-18
|
| pubmed:abstractText |
The treatment of psoriasis with high-dose exposure to oral psoralen and ultraviolet-A light (i.e., PUVA) substantially increases the risk of cutaneous squamous cell cancer, but not of basal cell cancer, within a decade of beginning treatment. To assess the persistence of cancer risk among individuals treated with PUVA, including those who discontinued therapy long ago and those without substantial exposure to other carcinogens, we prospectively studied a cohort of 1380 patients with psoriasis who were first treated during the period from January 1, 1975, through October 1, 1976, and evaluated risk factors associated with the development of cutaneous squamous cell cancers and basal cell cancers after 1985.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0027-8874
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
90
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1278-84
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9731734-Administration, Oral,
pubmed-meshheading:9731734-Adult,
pubmed-meshheading:9731734-Analysis of Variance,
pubmed-meshheading:9731734-Carcinoma, Basal Cell,
pubmed-meshheading:9731734-Carcinoma, Squamous Cell,
pubmed-meshheading:9731734-Dose-Response Relationship, Radiation,
pubmed-meshheading:9731734-Female,
pubmed-meshheading:9731734-Ficusin,
pubmed-meshheading:9731734-Follow-Up Studies,
pubmed-meshheading:9731734-Humans,
pubmed-meshheading:9731734-Male,
pubmed-meshheading:9731734-Photochemotherapy,
pubmed-meshheading:9731734-Photosensitizing Agents,
pubmed-meshheading:9731734-Prospective Studies,
pubmed-meshheading:9731734-Psoriasis,
pubmed-meshheading:9731734-Risk Factors,
pubmed-meshheading:9731734-Skin Neoplasms,
pubmed-meshheading:9731734-Ultraviolet Rays
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Oral psoralen and ultraviolet-A light (PUVA) treatment of psoriasis and persistent risk of nonmelanoma skin cancer. PUVA Follow-up Study.
|
| pubmed:affiliation |
Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. rstern@bidmc.harvard.edu
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Multicenter Study
|