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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1998-9-22
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pubmed:abstractText |
Gene transfer with recombinant viral vectors encoding vasodilator proteins may be useful in therapy of cerebral vasospasm after subarachnoid hemorrhage (SAH). Relaxations mediated by nitric oxide are impaired in cerebral arteries affected by SAH. The present study was designed to determine the effect of SAH on the efficiency of ex vivo adenovirus-mediated gene transfer to canine basilar arteries and to examine whether expression of recombinant endothelial nitric oxide synthase (eNOS) gene may have functional effects on vasomotor reactivity of spastic arteries affected by SAH.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0039-2499
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1959-65; discussion 1965-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9731624-Adenoviridae,
pubmed-meshheading:9731624-Animals,
pubmed-meshheading:9731624-Basilar Artery,
pubmed-meshheading:9731624-Bradykinin,
pubmed-meshheading:9731624-Dogs,
pubmed-meshheading:9731624-Enzyme Inhibitors,
pubmed-meshheading:9731624-Female,
pubmed-meshheading:9731624-Gene Therapy,
pubmed-meshheading:9731624-Genes, Reporter,
pubmed-meshheading:9731624-Male,
pubmed-meshheading:9731624-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:9731624-Nitric Oxide Synthase,
pubmed-meshheading:9731624-Nitric Oxide Synthase Type III,
pubmed-meshheading:9731624-Subarachnoid Hemorrhage,
pubmed-meshheading:9731624-Substance P,
pubmed-meshheading:9731624-Vasoconstriction,
pubmed-meshheading:9731624-Vasodilation,
pubmed-meshheading:9731624-beta-Galactosidase
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pubmed:year |
1998
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pubmed:articleTitle |
Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery after experimental subarachnoid hemorrhage.
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pubmed:affiliation |
Department of Anesthesiology, Mayo Medical Center, Rochester, Minn 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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