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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-9-28
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pubmed:abstractText |
The adipocyte-specific protein leptin signals the size of the adipose tissue mass to hypothalamic regions, thereby influencing food intake and energy metabolism. Human obesity is often associated with high leptin levels implying leptin resistance or defective leptin function. Two leptin mRNA species differing only by the presence or absence of a CAG codon encoding glutamine at position 49 of the mature protein arise from alternative splicing owing to two splice acceptor sites immediately following each other at the intron 2 - exon 3 junction. Since glutamine 49 is part of a highly conserved region, we studied possible functional implications of alternative splicing for human obesity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-8923
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
390-6
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pubmed:dateRevised |
2007-12-5
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pubmed:meshHeading |
pubmed-meshheading:9730492-Adipocytes,
pubmed-meshheading:9730492-Adipose Tissue,
pubmed-meshheading:9730492-Adult,
pubmed-meshheading:9730492-Alternative Splicing,
pubmed-meshheading:9730492-Blotting, Northern,
pubmed-meshheading:9730492-Blotting, Southern,
pubmed-meshheading:9730492-DNA, Complementary,
pubmed-meshheading:9730492-Female,
pubmed-meshheading:9730492-Gene Expression,
pubmed-meshheading:9730492-Humans,
pubmed-meshheading:9730492-Leptin,
pubmed-meshheading:9730492-Male,
pubmed-meshheading:9730492-Obesity, Morbid,
pubmed-meshheading:9730492-Peritoneal Cavity,
pubmed-meshheading:9730492-Point Mutation,
pubmed-meshheading:9730492-Polymerase Chain Reaction,
pubmed-meshheading:9730492-Proteins,
pubmed-meshheading:9730492-RNA,
pubmed-meshheading:9730492-RNA, Messenger
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pubmed:year |
1997
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pubmed:articleTitle |
Human obese gene expression: alternative splicing of mRNA and relation to adipose tissue localization.
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pubmed:affiliation |
Department of Laboratory Medicine, Landeskrankenanstalten Salzburg, Austria.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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