Linked Life Data

9730116

Source:http://linkedlifedata.com/resource/pubmed/id/9730116

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-11-18
pubmed:abstractText
Transection of the dorsal spinal column in monkeys has been previously shown to spare detection, localization and a variety of discriminations between spatial attributes of tactile stimuli. In contrast, performance on certain tests involving stimulus sequences is substantially impaired, such as tactile direction sensitivity and frequency discrimination. The present study extends these findings to show that a repetitive cutaneous stimulus is undetectable following complete interruption of the ipsilateral dorsal column. Macaca arctoides monkeys were trained to discriminate between different durations of 10 Hz indentation of the glabrous skin of one foot. Preoperatively, these animals could discriminate reliably between three pulses (the standard stimulus duration of 200 ms) and comparison trains of six or more pulses (500 ms or more). Following incomplete interruption of the ipsilateral dorsal column of one monkey, discrimination of the duration of stimulation was unimpaired. However, complete lesions of the ipsilateral dorsal column eliminated performance above the criterion of 75% correct responses for approximately 1 year of postoperative testing of three monkeys. Comparison stimuli of as many as 38 pulses (3.7 s) were utilized during postoperative testing. The inability to detect repetitive stimulation is hypothesized to be related to abnormal intracortical inhibition that has been demonstrated to occur within the primary somatosensory cortex (SI) of monkeys after interruption of the contralateral dorsal column.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0899-0220
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-63
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Impaired detection of repetitive stimulation following interruption of the dorsal spinal column in primates.
pubmed:affiliation
Department of Neuroscience, University of Florida College of Medicine, Gainesville 32610-0244, USA. vierck@ufbi.ufl.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't