Linked Life Data

9730090

Source:http://linkedlifedata.com/resource/pubmed/id/9730090

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
1998-11-30
pubmed:abstractText
Infections are a major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes --which play a crucial role in host defence against viral infections--, are divided in subsets based upon the expression of several cell and activation markers. In senescence changes and variations in peripheral CD8+ T lymphocyte compartment have been described, and such a decrease in the CD8+CD45RA+ lymphocytes. In this report the T V alpha and Vbeta cell specificities repertoire usage in aging subjects were studied by the use of seven different monoclonal antibodies specific for defined regions of the TCR. Except for the Vbeta6subfamily, no differences between old and control subjects in frequency of T cells bearing selected V alphabeta epitopes, were observed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0882-0139
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
T cell receptor V-segment frequencies in peripheral CD8+ T cells in aging.
pubmed:affiliation
Department of Physiology, School of Medicine, Universidad del País Vasco, Bilbao, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't