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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0077503,
umls-concept:C0245662,
umls-concept:C0332453,
umls-concept:C0599894,
umls-concept:C0667830,
umls-concept:C1420806,
umls-concept:C1516338,
umls-concept:C1521840,
umls-concept:C1539477
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pubmed:issue |
2
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pubmed:dateCreated |
1998-9-22
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pubmed:abstractText |
Homozygous targeted disruption of the mouse Caspase 8 (Casp8) gene was found to be lethal in utero. The Caspase 8 null embryos exhibited impaired heart muscle development and congested accumulation of erythrocytes. Recovery of hematopoietic colony-forming cells from the embryos was very low. In fibroblast strains derived from these embryos, the TNF receptors, Fas/Apo1, and DR3 were able to activate the Jun N-terminal kinase and to trigger IkappaB alpha phosphorylation and degradation. They failed, however, to induce cell death, while doing so effectively in wild-type fibroblasts. These findings indicate that Caspase 8 plays a necessary and nonredundant role in death induction by several receptors of the TNF/NGF family and serves a vital role in embryonal development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Casp8 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Casp9 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf25 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1074-7613
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pubmed:author |
pubmed-author:AvrahamK BKB,
pubmed-author:BeckmannJ SJS,
pubmed-author:BrodianskiV MVM,
pubmed-author:ChiannilkulchaiNN,
pubmed-author:GoncharovTT,
pubmed-author:HoltmannHH,
pubmed-author:KemperO COC,
pubmed-author:KollerMM,
pubmed-author:LapidotTT,
pubmed-author:LonaiPP,
pubmed-author:LurieRR,
pubmed-author:MettI LIL,
pubmed-author:RebrikovDD,
pubmed-author:SchuchmannMM,
pubmed-author:SobeTT,
pubmed-author:SofferDD,
pubmed-author:VarfolomeevE EEE,
pubmed-author:WallaceAA
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-76
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9729047-Animals,
pubmed-meshheading:9729047-Antigens, CD95,
pubmed-meshheading:9729047-Caspase 8,
pubmed-meshheading:9729047-Caspase 9,
pubmed-meshheading:9729047-Caspases,
pubmed-meshheading:9729047-Cell Death,
pubmed-meshheading:9729047-Cells, Cultured,
pubmed-meshheading:9729047-Cysteine Endopeptidases,
pubmed-meshheading:9729047-DNA, Complementary,
pubmed-meshheading:9729047-Fetal Death,
pubmed-meshheading:9729047-Fibroblasts,
pubmed-meshheading:9729047-Gene Targeting,
pubmed-meshheading:9729047-Genes, Lethal,
pubmed-meshheading:9729047-Gestational Age,
pubmed-meshheading:9729047-Mice,
pubmed-meshheading:9729047-Mice, Inbred C57BL,
pubmed-meshheading:9729047-Mice, Knockout,
pubmed-meshheading:9729047-Phenotype,
pubmed-meshheading:9729047-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:9729047-Receptors, Tumor Necrosis Factor, Member 25,
pubmed-meshheading:9729047-Transcription, Genetic
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pubmed:year |
1998
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pubmed:articleTitle |
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
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pubmed:affiliation |
Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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