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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1998-9-21
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pubmed:abstractText |
VegT is a T-box transcription factor whose mRNA is synthesized during oogenesis and localized in the vegetal hemisphere of the egg and early embryo. We show that maternally expressed VegT controls the pattern of primary germ layer specification in Xenopus embryos. Reduction of the maternal store completely alters the fates of different regions of the blastula so that animal cell fate is changed from epidermis and nervous system to epidermis only, equatorial cell fate is changed from mesoderm to ectoderm, and vegetal cell fate is changed from endoderm to mesoderm and ectoderm. Vegetal cells lose their capacity both to form endoderm and to release mesoderm-inducing signals. These results show that a single maternally expressed gene controls the patterning of the Xenopus blastula.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
515-24
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9727494-Animals,
pubmed-meshheading:9727494-Antigens, Differentiation,
pubmed-meshheading:9727494-Body Patterning,
pubmed-meshheading:9727494-DNA-Binding Proteins,
pubmed-meshheading:9727494-Ectoderm,
pubmed-meshheading:9727494-Embryonic Induction,
pubmed-meshheading:9727494-Epidermis,
pubmed-meshheading:9727494-Female,
pubmed-meshheading:9727494-Germ Layers,
pubmed-meshheading:9727494-Mesoderm,
pubmed-meshheading:9727494-Models, Biological,
pubmed-meshheading:9727494-Nervous System,
pubmed-meshheading:9727494-Phenotype,
pubmed-meshheading:9727494-RNA, Messenger,
pubmed-meshheading:9727494-T-Box Domain Proteins,
pubmed-meshheading:9727494-Transcription Factors,
pubmed-meshheading:9727494-Xenopus,
pubmed-meshheading:9727494-Xenopus Proteins,
pubmed-meshheading:9727494-Zygote
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pubmed:year |
1998
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pubmed:articleTitle |
The role of maternal VegT in establishing the primary germ layers in Xenopus embryos.
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pubmed:affiliation |
University of Miami School of Medicine, Department of Cell Biology and Anatomy, Florida 33136, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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