Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1998-12-9
|
| pubmed:abstractText |
Higher dietary salt intake in humans is associated with higher BP, but the BP response to NaCl, so-called salt sensitivity, is heterogeneous among individuals. It has been postulated that modifications in cellular cation metabolism may be related to salt sensitivity in mammalian hypertension. The authors have isolated a novel rat complementary DNA, called salt-tolerant protein (STP), that can functionally complement Saccharomyces cervisiae HAL1, which improves salt tolerance by modulating the cation transport system. On high-salt (8% NaCl) diets, both Dahl salt-sensitive and salt-resistant rats displayed an elevated BP and increased STP mRNA expression. Immunohistochemistry using an anti-rat STP antibody demonstrated the presence of STP immunoreactivity in the proximal tubules. In cells that transiently expressed STP, the intracellular [Na+]/[K+] ratio was higher than that in control cells. STP contains predicted coiled-coil and Src homology 3 domains, and shows a partially high degree of nucleotide identity to human thyroid-hormone receptor interacting protein. These results suggest that STP may play an important role in salt sensitivity through cellular sodium metabolism by mediating signal transduction and a hormone-dependent transcription mechanism.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Trip10 protein, rat
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1046-6673
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1574-80
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9727364-Amino Acid Sequence,
pubmed-meshheading:9727364-Analysis of Variance,
pubmed-meshheading:9727364-Animals,
pubmed-meshheading:9727364-Blotting, Northern,
pubmed-meshheading:9727364-Carrier Proteins,
pubmed-meshheading:9727364-Culture Techniques,
pubmed-meshheading:9727364-DNA, Complementary,
pubmed-meshheading:9727364-Disease Models, Animal,
pubmed-meshheading:9727364-Fungal Proteins,
pubmed-meshheading:9727364-Gene Expression,
pubmed-meshheading:9727364-Immunohistochemistry,
pubmed-meshheading:9727364-Kidney Cortex,
pubmed-meshheading:9727364-Kidney Medulla,
pubmed-meshheading:9727364-Male,
pubmed-meshheading:9727364-Microtubule-Associated Proteins,
pubmed-meshheading:9727364-RNA, Messenger,
pubmed-meshheading:9727364-Rats,
pubmed-meshheading:9727364-Rats, Inbred Dahl,
pubmed-meshheading:9727364-Rats, Wistar,
pubmed-meshheading:9727364-Sodium Chloride, Dietary
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Function and expression of a novel rat salt-tolerant protein: evidence of a role in cellular sodium metabolism.
|
| pubmed:affiliation |
Second Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
|