Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
1998-9-28
pubmed:abstractText
Determinative events in vertebrate embryogenesis appear to require the continuous expression of spatial regulators such as the clustered homeobox genes. The mechanisms that govern long-term patterns of gene expression are not well understood. In Drosophila, active and silent states of developmentally regulated loci are maintained by trithorax and Polycomb group. We have examined the developmental role of a mammalian homolog of trx and putative oncogene, Mll. Knockout mice reveal that Mll is required for maintenance of gene expression early in embryogenesis. Downstream targets of Mll including Hoxa7 are activated appropriately in the absence of Mll but require Mll for sustaining their expression. The Mll-/- phenotype manifests later in development and is characterized by branchial arch dysplasia and aberrant segmental boundaries of spinal ganglia and somites. Thus, Mll represents an essential mechanism of transcriptional maintenance in mammalian development, which functions in multiple morphogenetic processes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-103000, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-1283734, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-1363229, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-1400587, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-1423624, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-1423625, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-1680044, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-1685116, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-1870982, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-1978325, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-2193147, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-2627888, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-5041191, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-7477409, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-7744011, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-7912569, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-7924996, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-7958911, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-8074321, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-8096483, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-8224839, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-8231863, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-8445390, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-8608939, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-8625838, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-8887324, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-9153995, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-9214638, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-9292512, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-9309179, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-9367423, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-9463359, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-9524129, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-9539705, http://linkedlifedata.com/resource/pubmed/commentcorrection/9724755-9590168
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10632-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis.
pubmed:affiliation
Howard Hughes Medical Institute, Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't