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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1998-11-24
|
| pubmed:abstractText |
The effects of ribavirin and interferon (IFN) alpha have been investigated on cultured peripheral blood mononuclear cells, obtained from 15 patients with chronic hepatitis C virus (HCV) infection. At clinically relevant serum concentrations achieved during therapeutic administration, ribavirin did inhibit moderately the mitogen-stimulated mononuclear cell proliferation and growth of the CD4+ and CD8+ T cell subsets without apparent cytolysis. The ribavirin-IFN-alpha combination showed activity against HCV with disappearance of HCV RNA in 27% of cases, and a synergy in the inducibility of the intracellular enzyme 2',5'-oligoadenylate synthetase. Such ribavirin concentrations induced modest increases in the T helper 1-like cytokine production by mononuclear cells. Higher ribavirin concentrations markedly inhibited IFN-gamma production, but augmented interleukins (IL) 2, 4, and 12 secretion. Conversely, IFN-alpha tended to suppress IL 2, 4 and 12, but enhanced IFN-gamma and IL-10 secretion. Thus, ribavirin and IFN-alpha appear to cause diverse effects on immunoregulatory cytokine secretion, and when combined, counteracted for production of IL-2 and IL-12, while upregulated mononuclear cell secretion of IFN-gamma and that of the anti-inflammatory cytokine IL-10. These findings suggest a non-cytolytic modulation of inflammatory responses induced by the drug combination, that may be relevant in the pathophysiology of chronic HCV infection.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2',5'-Oligoadenylate Synthetase,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribavirin,
http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2a
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1043-4666
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
635-44
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9722937-2',5'-Oligoadenylate Synthetase,
pubmed-meshheading:9722937-Adult,
pubmed-meshheading:9722937-Aged,
pubmed-meshheading:9722937-Antiviral Agents,
pubmed-meshheading:9722937-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9722937-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9722937-Cell Division,
pubmed-meshheading:9722937-Cells, Cultured,
pubmed-meshheading:9722937-Cytokines,
pubmed-meshheading:9722937-Drug Interactions,
pubmed-meshheading:9722937-Enzyme Activation,
pubmed-meshheading:9722937-Hepacivirus,
pubmed-meshheading:9722937-Hepatitis C, Chronic,
pubmed-meshheading:9722937-Humans,
pubmed-meshheading:9722937-Interferon-alpha,
pubmed-meshheading:9722937-Leukocytes, Mononuclear,
pubmed-meshheading:9722937-Middle Aged,
pubmed-meshheading:9722937-RNA, Viral,
pubmed-meshheading:9722937-Recombinant Proteins,
pubmed-meshheading:9722937-Ribavirin
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Effects of the ribavirin-interferon alpha combination on cultured peripheral blood mononuclear cells from chronic hepatitis C patients.
|
| pubmed:affiliation |
Department of Hepatology, Fundación Jiménez Díaz, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|