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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1998-12-22
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pubmed:abstractText |
Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and continued study promises a better understanding of the nature of protective immune responses. Recent evidence supports involvement of both cytotoxic T lymphocytes and neutralizing antibodies in protective immunity against infection by simian immunodeficiency virus, but more detailed studies are needed to document their relative importance.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0952-7915
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
436-43
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9722920-Animals,
pubmed-meshheading:9722920-Antibody Formation,
pubmed-meshheading:9722920-Gene Products, nef,
pubmed-meshheading:9722920-Humans,
pubmed-meshheading:9722920-Immunity, Cellular,
pubmed-meshheading:9722920-Macaca,
pubmed-meshheading:9722920-Mutagenesis,
pubmed-meshheading:9722920-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:9722920-Simian immunodeficiency virus,
pubmed-meshheading:9722920-Sterilization,
pubmed-meshheading:9722920-Vaccination,
pubmed-meshheading:9722920-Vaccines, Attenuated,
pubmed-meshheading:9722920-Viral Interference,
pubmed-meshheading:9722920-Viral Vaccines
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pubmed:year |
1998
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pubmed:articleTitle |
Protective immunity induced by live attenuated simian immunodeficiency virus.
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pubmed:affiliation |
Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA. pjohnson@warren.med.harvard.edu
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pubmed:publicationType |
Journal Article,
Review
|