|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
1998-10-19
|
|
pubmed:abstractText |
A new 10-keto bis-tetrahydrofuran acetogenin, guanacone (1), has been isolated from a cytotoxic extract of Annona aff. spraguei seeds. The 10-oximeguanacone derivative 1f is the first bioactive nitrogenated acetogenin found to be a very potent inhibitor of complex I. In addition, a SAR study of guanacone analogues is reported based on the titration of the NADH oxidase and NADH:ubiquinone oxidoreductase activities.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0163-3864
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
61
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1001-5
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9722484-Animals,
pubmed-meshheading:9722484-Antimetabolites, Antineoplastic,
pubmed-meshheading:9722484-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:9722484-Cattle,
pubmed-meshheading:9722484-Electron Transport,
pubmed-meshheading:9722484-Furans,
pubmed-meshheading:9722484-Lactones,
pubmed-meshheading:9722484-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9722484-Mass Spectrometry,
pubmed-meshheading:9722484-Mitochondria, Heart,
pubmed-meshheading:9722484-Plants, Medicinal,
pubmed-meshheading:9722484-Seeds,
pubmed-meshheading:9722484-Spectrophotometry, Infrared,
pubmed-meshheading:9722484-Spectrophotometry, Ultraviolet
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
10-Oximeguanacone, the first nitrogenated acetogenin derivative found to be a potent inhibitor of mitochondrial complex I.
|
|
pubmed:affiliation |
Departamento de Farmacología, Universidad de Valencia, 46100 Burjassot, Valencia, Spain.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
