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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1998-11-25
|
| pubmed:abstractText |
Lung surfactant deficiency contributes to the pathophysiology of congenital diaphragmatic hernia (CDH) and the high neonatal mortality rate. Acceleration of lung surfactant system maturation by prenatal administration of hormones has been described in animal models of CDH. However, in utero tracheal ligation (TL) is the best method to accelerate lung growth and reverse the pulmonary hypoplasia associated with CDH. Although this method offers promise, its application in humans is limited. The aim of this study was to investigate a new noninvasive therapeutic strategy, that is, the prenatal intraamniotic administration of exogenous porcine surfactant or dexamethasone, and compare it with the effects of TL in an animal model of CDH.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-3468
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1198-205
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9721986-Analysis of Variance,
pubmed-meshheading:9721986-Animals,
pubmed-meshheading:9721986-Anti-Inflammatory Agents,
pubmed-meshheading:9721986-Dexamethasone,
pubmed-meshheading:9721986-Disease Models, Animal,
pubmed-meshheading:9721986-Embryonic and Fetal Development,
pubmed-meshheading:9721986-Female,
pubmed-meshheading:9721986-Hernia, Diaphragmatic,
pubmed-meshheading:9721986-Injections, Intralesional,
pubmed-meshheading:9721986-Ligation,
pubmed-meshheading:9721986-Lung,
pubmed-meshheading:9721986-Lung Diseases,
pubmed-meshheading:9721986-Organ Size,
pubmed-meshheading:9721986-Pregnancy,
pubmed-meshheading:9721986-Rabbits,
pubmed-meshheading:9721986-Reference Values,
pubmed-meshheading:9721986-Surface-Active Agents,
pubmed-meshheading:9721986-Trachea
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
The effects of prenatal intraamniotic surfactant or dexamethasone administration on lung development are comparable to changes induced by tracheal ligation in an animal model of congenital diaphragmatic hernia.
|
| pubmed:affiliation |
Pediatric Surgery Division, University of São Paulo Medical School, Brazil.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|