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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1998-12-1
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pubmed:abstractText |
The physicochemical properties, mechanisms of synthesis and decomposition of dinitrosyl iron complexes (DNICs) with thiol-containing ligands and of S-nitrosothiols (RS-NO), and the potential role of these compounds in storage and transport of NO in biological systems are reviewed. Special attention is given to the phenomenon of mutual transformation of DNIC and RS-NO catalyzed by Fe2+. Each Fe2+ binds two neutral NO molecules in the DNICs, catalyzes their mutual oxidation--reduction with formation of nitrous oxide and nitrosonium ions appearing in the DNICs. These ions S-nitrosate thiol-compounds with RS-NO formation. Fe2+ binds two RS-NO molecules and catalyzes their mutual oxidation--reduction followed by decomposition of the resulting molecules. Mutual conversion of DNICs and RS-NO regulated by iron, thiol, and NO levels is suggested to provide NO transport in cells and tissues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-2979
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
782-93
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9721330-Animals,
pubmed-meshheading:9721330-Biological Transport, Active,
pubmed-meshheading:9721330-Chemistry, Physical,
pubmed-meshheading:9721330-Drug Stability,
pubmed-meshheading:9721330-Electron Spin Resonance Spectroscopy,
pubmed-meshheading:9721330-Humans,
pubmed-meshheading:9721330-Hydrogen-Ion Concentration,
pubmed-meshheading:9721330-Iron,
pubmed-meshheading:9721330-Mercaptoethanol,
pubmed-meshheading:9721330-Nitric Oxide,
pubmed-meshheading:9721330-Nitrogen Oxides,
pubmed-meshheading:9721330-Nitroso Compounds,
pubmed-meshheading:9721330-Physicochemical Phenomena,
pubmed-meshheading:9721330-S-Nitrosothiols
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pubmed:year |
1998
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pubmed:articleTitle |
Dinitrosyl iron complexes and S-nitrosothiols are two possible forms for stabilization and transport of nitric oxide in biological systems.
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pubmed:affiliation |
Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 117977, Russia. mikoyan@center.chph.ras.ru
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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