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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1998-10-5
|
| pubmed:databankReference | |
| pubmed:abstractText |
MSG1 (melanocyte-specific gene 1) is a recently isolated gene predominantly expressed in cultured normal melanocytes and pigmented melanoma cells. MSG1 encodes a 27-kDa nuclear protein that has strong intrinsic transcriptional transactivating activity. In this report, the human MSG1 gene was mapped to chromosome Xq13.1 using X chromosome-specific somatic cell hybrids, and the mouse Msg1 gene was mapped 1.9 +/- 1.3 cM proximal to Xist using an interspecific backcross panel. Both the human and the mouse MSG1 genes consist of three exons and two introns within 5 kb of genomic DNA, and their genomic structures are highly conserved. Southern blot analysis suggests the existence of MSG1 homologues in chicken, zebrafish, and Drosophila. A 2.0-kb fragment of the 5'-flanking region of the mouse Msg1 gene contains a TATA box and potential binding sites for several transcription factors including USF, Brn-3, Brn-2, TFE3, Oct-1, AP-2, and Spl. This promoter fragment activates transcription of a reporter gene in pigmented melanoma cells, but not in amelanotic melanoma cells or nonmelanocytic cells, indicating that Msg1 expression is at least partially regulated at the transcriptional level.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CITED1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cited1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0888-7543
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1998 Academic Press.
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
401-7
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9721210-Animals,
pubmed-meshheading:9721210-Base Sequence,
pubmed-meshheading:9721210-Chromosome Mapping,
pubmed-meshheading:9721210-Cloning, Molecular,
pubmed-meshheading:9721210-Conserved Sequence,
pubmed-meshheading:9721210-Exons,
pubmed-meshheading:9721210-Genes, Reporter,
pubmed-meshheading:9721210-Humans,
pubmed-meshheading:9721210-Introns,
pubmed-meshheading:9721210-Mice,
pubmed-meshheading:9721210-Molecular Sequence Data,
pubmed-meshheading:9721210-Nuclear Proteins,
pubmed-meshheading:9721210-Promoter Regions, Genetic,
pubmed-meshheading:9721210-Sequence Analysis, DNA,
pubmed-meshheading:9721210-TATA Box,
pubmed-meshheading:9721210-Trans-Activators,
pubmed-meshheading:9721210-Transcription, Genetic,
pubmed-meshheading:9721210-Transcription Factors,
pubmed-meshheading:9721210-Tumor Cells, Cultured,
pubmed-meshheading:9721210-X Chromosome
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis.
|
| pubmed:affiliation |
Laboratory of Tumor Biology, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|