Linked Life Data

9718338

Source:http://linkedlifedata.com/resource/pubmed/id/9718338

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-10-20
pubmed:abstractText
We considered the problem of testing a marker for linkage with a disease, using tests based on the transmission-disequilibrium test (TDT). The power of such tests was investigated for a number of possible family types, for which the families were classified by the disease status of family individuals. We show that parental disease status greatly affects the power, with families containing a single affected parent often preferred over families in which neither parent is affected. Families with a pair of affected sibs are of great value for all situations considered, but extension of the TDT to allow inclusion of information from unaffected sibs rarely increases power, if the parents have been genotyped.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-9297
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
889-97
pubmed:dateRevised
2008-11-20
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
The effect of family structure on linkage tests using allelic association.
pubmed:affiliation
Department of Applied Statistics, University of Reading, Reading, United Kingdom. j.c.whittaker@reading.ac.uk
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.