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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1976-12-3
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pubmed:abstractText |
alpha-Chlorohydrin (I) is oxidatively metabolized to beta-chlorolactic acid (III) and oxalic acid (IV). Deposition of calcium oxalate within the renal tubules is responsible for the toxic effects of alpha-chlorohydrin and a similar action on the epididymis or epididymal blood vessels could initiate the formation of spermatocoeles from this and other male antifertility agents.
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/ALCOHOLS,
http://linkedlifedata.com/resource/pubmed/keyword/Alpha-chlorohydrin,
http://linkedlifedata.com/resource/pubmed/keyword/Animals, Laboratory,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Male,
http://linkedlifedata.com/resource/pubmed/keyword/Epididymis,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia, Male,
http://linkedlifedata.com/resource/pubmed/keyword/Ingredients And Chemicals,
http://linkedlifedata.com/resource/pubmed/keyword/Organic Chemicals,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Sperm Maturation Blocking Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Testis,
http://linkedlifedata.com/resource/pubmed/keyword/Urogenital System
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-4754
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1135-6
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pubmed:dateRevised |
2003-11-14
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pubmed:otherAbstract |
PIP: The oxidative metabolism of alpha-chlorohydrin and the chemical indu ction of spermatocoeles are described. Alpha-chlorohydrin was oxidative ly metabolized to beta-chlorolactic acid and oxalic acid. Deposition of calcium oxalate within the renal tubules was responsible for the toxic effects of alpha-chlorohydrin and a similar action on the epididymis or epididymal blood vessels may initiate the formation of spermatocoeles from this and other male antifertility agents.
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pubmed:meshHeading |
pubmed-meshheading:971742-Animals,
pubmed-meshheading:971742-Anuria,
pubmed-meshheading:971742-Diuresis,
pubmed-meshheading:971742-Kidney Failure, Chronic,
pubmed-meshheading:971742-Kidney Tubules,
pubmed-meshheading:971742-Lactates,
pubmed-meshheading:971742-Male,
pubmed-meshheading:971742-Oxalates,
pubmed-meshheading:971742-Rats,
pubmed-meshheading:971742-Spermatocele
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pubmed:year |
1976
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pubmed:articleTitle |
The oxidative metabolism of alpha-chlorohydrin and the chemical induction of spermatocoeles.
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pubmed:publicationType |
Journal Article
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