| pubmed-article:9716576 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9716576 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:9716576 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:9716576 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:9716576 | lifeskim:mentions | umls-concept:C1416525 | lld:lifeskim |
| pubmed-article:9716576 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9716576 | lifeskim:mentions | umls-concept:C1947989 | lld:lifeskim |
| pubmed-article:9716576 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:9716576 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9716576 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9716576 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9716576 | pubmed:dateCreated | 1998-9-10 | lld:pubmed |
| pubmed-article:9716576 | pubmed:abstractText | The Notch signaling system regulates proliferation and differentiation in many tissues. Notch is a transmembrane receptor activated by ligands expressed on adjacent cells. Hematopoietic stem cells and early progenitors express Notch, making the stromal cells which form cell-cell contacts with progenitor cells candidate ligand-presenting cells in the hematopoietic microenvironment. Therefore, we examined primary stromal cell cultures for expression of Notch ligands. Using reverse transcription-polymerase chain reaction, in situ hybridization, immunohistochemistry, and Western blotting, we demonstrate expression of Jagged 1 in primary stromal cultures. To investigate if the stromal expression of Jagged 1 has functional effects on hematopoietic progenitors, we cultured CD34(+), c-kit+ hematopoietic progenitor cells derived from the aorto gonadal mesonephros region of day 11 mouse embryos on the Jagged 1(-) stromal cell line S17 and on S17 cells engineered to express Jagged 1. The presence of Jagged 1 increased the number of colonies formed in subsequent methylcellulose culture fourfold. Larger increases in colony numbers were observed under the same culture conditions with CD34(+), c-kit+ hematopoietic progenitor cells derived from d11 fetal liver. These results obtained in vitro table Jagged 1 as a candidate regulator of stem cell fate in the context of stromal microenvironments in vivo. | lld:pubmed |
| pubmed-article:9716576 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9716576 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716576 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9716576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9716576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716576 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9716576 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9716576 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:9716576 | pubmed:author | pubmed-author:JonesPP | lld:pubmed |
| pubmed-article:9716576 | pubmed:author | pubmed-author:BrownJJ | lld:pubmed |
| pubmed-article:9716576 | pubmed:author | pubmed-author:MayGG | lld:pubmed |
| pubmed-article:9716576 | pubmed:author | pubmed-author:HealyLL | lld:pubmed |
| pubmed-article:9716576 | pubmed:author | pubmed-author:DelassusSS | lld:pubmed |
| pubmed-article:9716576 | pubmed:author | pubmed-author:EnverTT | lld:pubmed |
| pubmed-article:9716576 | pubmed:author | pubmed-author:HoyneGG | lld:pubmed |
| pubmed-article:9716576 | pubmed:copyrightInfo | Copyright 1998 by The American Society of Hematology. | lld:pubmed |
| pubmed-article:9716576 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9716576 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9716576 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:9716576 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9716576 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9716576 | pubmed:pagination | 1505-11 | lld:pubmed |
| pubmed-article:9716576 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9716576 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9716576 | pubmed:articleTitle | Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells. | lld:pubmed |
| pubmed-article:9716576 | pubmed:affiliation | Section of Gene Function and Regulation & Leukaemia Research Fund Centre, Chester Beatty Laboratories, Institute of Cancer Research, London, UK. | lld:pubmed |
| pubmed-article:9716576 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9716576 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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