|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
18
|
|
pubmed:dateCreated |
1998-10-30
|
|
pubmed:abstractText |
In C. elegans, the epithelial Pn.p cells adopt either a vulval precursor cell fate or fuse with the surrounding hypodermis (the F fate). Our results suggest that a Wnt signal transduced through a pathway involving the beta-catenin homolog BAR-1 controls whether P3.p through P8.p adopt the vulval precursor cell fate. In bar-1 mutants, P3.p through P8.p can adopt F fates instead of vulval precursor cell fates. The Wnt/bar-1 signaling pathway acts by regulating the expression of the Hox gene lin-39, since bar-1 is required for LIN-39 expression and forced lin-39 expression rescues the bar-1 mutant phenotype. LIN-39 activity is also regulated by the anchor cell signal/let-23 receptor tyrosine kinase/let-60 Ras signaling pathway. Our genetic and molecular experiments show that the vulval precursor cells can integrate the input from the BAR-1 and LET-60 Ras signaling pathways by coordinately regulating activity of the common target LIN-39 Hox.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/let-23 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/let-60 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/lin-39 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0950-1991
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
125
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3667-80
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:9716532-Animals,
pubmed-meshheading:9716532-Body Patterning,
pubmed-meshheading:9716532-Cadherins,
pubmed-meshheading:9716532-Caenorhabditis elegans,
pubmed-meshheading:9716532-Caenorhabditis elegans Proteins,
pubmed-meshheading:9716532-Cell Differentiation,
pubmed-meshheading:9716532-Cytoskeletal Proteins,
pubmed-meshheading:9716532-Embryonic Development,
pubmed-meshheading:9716532-Female,
pubmed-meshheading:9716532-Gene Expression Regulation, Developmental,
pubmed-meshheading:9716532-Genes, Homeobox,
pubmed-meshheading:9716532-Helminth Proteins,
pubmed-meshheading:9716532-Homeodomain Proteins,
pubmed-meshheading:9716532-Receptor, Epidermal Growth Factor,
pubmed-meshheading:9716532-Signal Transduction,
pubmed-meshheading:9716532-Trans-Activators,
pubmed-meshheading:9716532-Vulva,
pubmed-meshheading:9716532-beta Catenin,
pubmed-meshheading:9716532-ras Proteins
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development.
|
|
pubmed:affiliation |
Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
