Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1998-9-16
pubmed:databankReference
pubmed:abstractText
Preventing or delaying progress through the cell cycle in response to DNA damage is crucial for eukaryotic cells to allow the damage to be repaired and not incorporated irrevocably into daughter cells. Several genes involved in this process have been discovered in fission and budding yeast. Here, we report the identification of human and mouse homologs of the Schizosaccharomyces pombe DNA damage checkpoint control gene rad1(+) and its Saccharomyces cerevisiae homolog RAD17. The human gene HRAD1 is located on chromosome 5p13 and is most homologous to S. pombe rad1(+). This gene encodes a 382-amino-acid residue protein that is localized mainly in the nucleus and is expressed at high levels in proliferative tissues. This human gene significantly complements the sensitivity to UV light of a S. pombe strain mutated in rad1(+). Moreover, HRAD1 complements the checkpoint control defect of this strain after UV exposure. In addition to functioning in DNA repair checkpoints, S. cerevisiae RAD17 plays a role during meiosis to prevent progress through prophase I when recombination is interrupted. Consistent with a similar role in mammals, Rad1 protein is abundant in testis, and is associated with both synapsed and unsynapsed chromosomes during meiotic prophase I of spermatogenesis, with a staining pattern distinct from that of the recombination proteins Rad51 and Dmc1. Together, these data imply an important role for hRad1 both in the mitotic DNA damage checkpoint and in meiotic checkpoint mechanisms, and suggest that these events are highly conserved from yeast to humans.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-1563349, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-1563350, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-1581960, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-2005825, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-2358444, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-2440900, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7491494, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7528104, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7545545, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7625768, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7667321, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7671309, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7671311, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7671312, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7675110, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7792600, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7876343, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7907943, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7926829, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-7958916, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8065923, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8276878, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8332516, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8533149, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8552404, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8574569, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8590806, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8610130, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8649984, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8673119, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8722772, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8765156, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8843194, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8843195, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8846774, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8852657, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8893012, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8929543, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8939848, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8943031, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-8978690, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9000145, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9039258, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9039259, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9039264, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9115420, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9143686, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9221807, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9251010, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9251042, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9254722, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9278511, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9311981, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9323140, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9334324, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9418885, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9427750, http://linkedlifedata.com/resource/pubmed/commentcorrection/9716408-9524127
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA Repair Enzymes, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Endonucleases, http://linkedlifedata.com/resource/pubmed/chemical/Exonucleases, http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RAD1 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/RAD17 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Rad1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Schizosaccharomyces pombe Proteins, http://linkedlifedata.com/resource/pubmed/chemical/rad1 protein, S pombe
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0890-9369
pubmed:author
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