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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6694
|
| pubmed:dateCreated |
1998-9-3
|
| pubmed:abstractText |
Fear conditioning is a paradigm that has been used as a model for emotional learning in animals. The cellular correlate of fear conditioning is thought to be associative N-methyl-D-aspartate (NMDA) receptor-dependent synaptic plasticity within the amygdala. Here we show that glutamatergic synaptic transmission to inhibitory interneurons in the basolateral amygdala is mediated solely by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. In contrast to AMPA receptors at inputs to pyramidal neurons, these receptors have an inwardly rectifying current-voltage relationship, indicative of a high permeability to calcium. Tetanic stimulation of inputs to interneurons caused an immediate and sustained increase in the efficacy of these synapses. This potentiation required a rise in postsynaptic calcium, but was independent of NMDA receptor activation. The potentiation of excitatory inputs to interneurons was reflected as an increase in the amplitude of the GABA(A)-mediated inhibitory synaptic current in pyramidal neurons. These results demonstrate that excitatory synapses onto interneurons within a fear conditioning circuit show NMDA-receptor independent long-term potentiation. This plasticity might underlie the increased synchronization of activity between neurons in the basolateral amygdala after fear conditioning.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor ionotropic...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0028-0836
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
13
|
| pubmed:volume |
394
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
683-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9716132-Amygdala,
pubmed-meshheading:9716132-Animals,
pubmed-meshheading:9716132-Calcium,
pubmed-meshheading:9716132-Cell Membrane Permeability,
pubmed-meshheading:9716132-Conditioning, Classical,
pubmed-meshheading:9716132-Electrophysiology,
pubmed-meshheading:9716132-Evoked Potentials,
pubmed-meshheading:9716132-Fear,
pubmed-meshheading:9716132-Interneurons,
pubmed-meshheading:9716132-Long-Term Potentiation,
pubmed-meshheading:9716132-Neural Inhibition,
pubmed-meshheading:9716132-Neurons,
pubmed-meshheading:9716132-Patch-Clamp Techniques,
pubmed-meshheading:9716132-Potassium,
pubmed-meshheading:9716132-Rats,
pubmed-meshheading:9716132-Rats, Wistar,
pubmed-meshheading:9716132-Receptors, AMPA,
pubmed-meshheading:9716132-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:9716132-Synaptic Transmission,
pubmed-meshheading:9716132-gamma-Aminobutyric Acid
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala.
|
| pubmed:affiliation |
The Neuroscience Group, Faculty of Medicine and Health Sciences, University of Newcastle, NSW, Australia.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|