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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-10-1
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pubmed:databankReference |
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pubmed:abstractText |
We have isolated a novel cDNA (HiAT3: hippocampus abundant transcript 3) in the course of screening for genes that are preferentially expressed in neonatal mouse hippocampus using random 3'-directed cDNA sequencing approach. It encodes a 180-aa protein that has high similarity to SCG10, a neuron-specific negative regulator of microtubule dynamics during neurite outgrowth. The expression of HiAT3 is limited to neurons and peaks about 1 week after birth. The identification of HiAT3 suggests that there may be an elaborate destabilizing regulation for microtubule dynamics in neurons in addition to the stabilizing effect of multiple microtubule-associated proteins (MAPs).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Stathmin,
http://linkedlifedata.com/resource/pubmed/chemical/Stmn1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Stmn2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Stmn3 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
215
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
477-81
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9714847-Amino Acid Sequence,
pubmed-meshheading:9714847-Animals,
pubmed-meshheading:9714847-Animals, Newborn,
pubmed-meshheading:9714847-Base Sequence,
pubmed-meshheading:9714847-Brain,
pubmed-meshheading:9714847-DNA, Complementary,
pubmed-meshheading:9714847-Gene Expression Regulation,
pubmed-meshheading:9714847-Hippocampus,
pubmed-meshheading:9714847-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:9714847-Mice,
pubmed-meshheading:9714847-Mice, Inbred C57BL,
pubmed-meshheading:9714847-Microtubule Proteins,
pubmed-meshheading:9714847-Microtubules,
pubmed-meshheading:9714847-Molecular Sequence Data,
pubmed-meshheading:9714847-Nerve Growth Factors,
pubmed-meshheading:9714847-Neurons,
pubmed-meshheading:9714847-Neuropeptides,
pubmed-meshheading:9714847-Organ Specificity,
pubmed-meshheading:9714847-Phosphoproteins,
pubmed-meshheading:9714847-Sequence Alignment,
pubmed-meshheading:9714847-Sequence Homology, Amino Acid,
pubmed-meshheading:9714847-Stathmin,
pubmed-meshheading:9714847-Transcription, Genetic
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pubmed:year |
1998
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pubmed:articleTitle |
A novel SCG10-related gene uniquely expressed in the nervous system.
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pubmed:affiliation |
Institute for Molecular, Cellular Biology, Osaka University, Yamada-oka, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article
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