|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
1998-8-17
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
We report the cloning and characterization of human PON2, a paraoxonase-related gene-2 that is physically linked with PON1 and PON3 on 7q2l.3. PON2 is ubiquitously expressed and we identified several mRNA forms produced by alternative splicing, or by the use of a second transcription start site. We also describe two polymorphisms in the coding sequences that, in the protein deduced from the longest open reading frame, predict an alanine-to-glycine substitution at residue 147 and a serine-to-cysteine substitution at residue 310.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0378-1119
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 1998 Elsevier Science B.V. All rights reserved.
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
213
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
149-57
|
|
pubmed:dateRevised |
2011-9-9
|
|
pubmed:meshHeading |
pubmed-meshheading:9714608-Amino Acid Sequence,
pubmed-meshheading:9714608-Aryldialkylphosphatase,
pubmed-meshheading:9714608-Base Sequence,
pubmed-meshheading:9714608-Chromosome Mapping,
pubmed-meshheading:9714608-Chromosomes, Human, Pair 7,
pubmed-meshheading:9714608-Cloning, Molecular,
pubmed-meshheading:9714608-Diabetes Mellitus, Type 2,
pubmed-meshheading:9714608-Disease Susceptibility,
pubmed-meshheading:9714608-Esterases,
pubmed-meshheading:9714608-Genes,
pubmed-meshheading:9714608-Humans,
pubmed-meshheading:9714608-Insulin Resistance,
pubmed-meshheading:9714608-Introns,
pubmed-meshheading:9714608-Molecular Sequence Data,
pubmed-meshheading:9714608-Open Reading Frames,
pubmed-meshheading:9714608-Polymorphism, Genetic,
pubmed-meshheading:9714608-RNA, Messenger,
pubmed-meshheading:9714608-RNA Splicing,
pubmed-meshheading:9714608-Sequence Alignment,
pubmed-meshheading:9714608-Sequence Homology, Amino Acid,
pubmed-meshheading:9714608-Transcription, Genetic
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence.
|
|
pubmed:affiliation |
Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Health, Phoenix, AZ 85016, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
