| pubmed-article:9714415 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9714415 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:9714415 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9714415 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:9714415 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9714415 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:9714415 | lifeskim:mentions | umls-concept:C2610891 | lld:lifeskim |
| pubmed-article:9714415 | lifeskim:mentions | umls-concept:C1963724 | lld:lifeskim |
| pubmed-article:9714415 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9714415 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9714415 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9714415 | pubmed:dateCreated | 1998-9-23 | lld:pubmed |
| pubmed-article:9714415 | pubmed:abstractText | Several lines of evidence suggest that Fas-mediated apoptosis is involved in the CD4 T-cell depletion in human immunodeficiency virus-1 (HIV-1) infection. To investigate this, we studied changes in peripheral blood, early T-cell apoptosis and Fas expression after initiation of antiretroviral therapy (ART) in 18 HIV-1-infected individuals. Flow cytometric analysis was performed with Apostain and CD4, CD8 and Fas staining. Fas expression was quantified by standardized beads. The levels of CD4 and CD8 T cells with early apoptosis were increased comparably in HIV-1-infected individuals. Despite elevated CD4 T cell counts, no decline in early T-cell apoptosis could be detected during the first 8 weeks of ART. However, after 26 weeks of ART in five patients that showed a sustained reduction of viral replication there was a marked decrease in T cells with features of early apoptosis. No difference was found for Fas expression on early apoptotic T cells. Fas expression on CD4 and CD8 T cells was reduced after initiation of ART; this was independent of the CD4 T-cell trend and indicates that the immediate CD4 T-cell expansion during ART is probably not the result of a decreased rate of early apoptosis among peripheral blood CD4 T cells. However, preliminary data imply a long-term reduction of early T-cell apoptosis and Fas expression in patients who show a sustained reduction of viral replication. | lld:pubmed |
| pubmed-article:9714415 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9714415 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9714415 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9714415 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9714415 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9714415 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9714415 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9714415 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9714415 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9714415 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:9714415 | pubmed:author | pubmed-author:SchaapTT | lld:pubmed |
| pubmed-article:9714415 | pubmed:author | pubmed-author:DennisR ERE | lld:pubmed |
| pubmed-article:9714415 | pubmed:author | pubmed-author:HansenFF | lld:pubmed |
| pubmed-article:9714415 | pubmed:author | pubmed-author:DalhoffKK | lld:pubmed |
| pubmed-article:9714415 | pubmed:author | pubmed-author:AriesS PSP | lld:pubmed |
| pubmed-article:9714415 | pubmed:author | pubmed-author:WeyrichKK | lld:pubmed |
| pubmed-article:9714415 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9714415 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:9714415 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9714415 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9714415 | pubmed:pagination | 86-91 | lld:pubmed |
| pubmed-article:9714415 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9714415 | pubmed:meshHeading | pubmed-meshheading:9714415-... | lld:pubmed |
| pubmed-article:9714415 | pubmed:meshHeading | pubmed-meshheading:9714415-... | lld:pubmed |
| pubmed-article:9714415 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9714415 | pubmed:articleTitle | Early T-cell apoptosis and Fas expression during antiretroviral therapy in individuals infected with human immunodeficiency virus-1. | lld:pubmed |
| pubmed-article:9714415 | pubmed:affiliation | Department of Medicine II, Medical University Lübeck, Germany. | lld:pubmed |
| pubmed-article:9714415 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9714415 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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