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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1998-9-23
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pubmed:abstractText |
Several lines of evidence suggest that Fas-mediated apoptosis is involved in the CD4 T-cell depletion in human immunodeficiency virus-1 (HIV-1) infection. To investigate this, we studied changes in peripheral blood, early T-cell apoptosis and Fas expression after initiation of antiretroviral therapy (ART) in 18 HIV-1-infected individuals. Flow cytometric analysis was performed with Apostain and CD4, CD8 and Fas staining. Fas expression was quantified by standardized beads. The levels of CD4 and CD8 T cells with early apoptosis were increased comparably in HIV-1-infected individuals. Despite elevated CD4 T cell counts, no decline in early T-cell apoptosis could be detected during the first 8 weeks of ART. However, after 26 weeks of ART in five patients that showed a sustained reduction of viral replication there was a marked decrease in T cells with features of early apoptosis. No difference was found for Fas expression on early apoptotic T cells. Fas expression on CD4 and CD8 T cells was reduced after initiation of ART; this was independent of the CD4 T-cell trend and indicates that the immediate CD4 T-cell expansion during ART is probably not the result of a decreased rate of early apoptosis among peripheral blood CD4 T cells. However, preliminary data imply a long-term reduction of early T-cell apoptosis and Fas expression in patients who show a sustained reduction of viral replication.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0300-9475
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
86-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9714415-Adult,
pubmed-meshheading:9714415-Anti-HIV Agents,
pubmed-meshheading:9714415-Antigens, CD95,
pubmed-meshheading:9714415-Apoptosis,
pubmed-meshheading:9714415-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9714415-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9714415-Drug Therapy, Combination,
pubmed-meshheading:9714415-Female,
pubmed-meshheading:9714415-HIV Infections,
pubmed-meshheading:9714415-HIV Protease Inhibitors,
pubmed-meshheading:9714415-HIV-1,
pubmed-meshheading:9714415-Humans,
pubmed-meshheading:9714415-Male,
pubmed-meshheading:9714415-Middle Aged,
pubmed-meshheading:9714415-Reverse Transcriptase Inhibitors,
pubmed-meshheading:9714415-Time Factors,
pubmed-meshheading:9714415-Viral Load
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pubmed:year |
1998
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pubmed:articleTitle |
Early T-cell apoptosis and Fas expression during antiretroviral therapy in individuals infected with human immunodeficiency virus-1.
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pubmed:affiliation |
Department of Medicine II, Medical University Lübeck, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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