Linked Life Data

9714320

Source:http://linkedlifedata.com/resource/pubmed/id/9714320

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1998-9-14
pubmed:abstractText
The ability of adrenergic catechol derivatives, including dobutamine, dopamine, and isoproterenol, to inhibit lipid peroxidation was examined. All the catechol derivatives we tested strongly inhibited lipid peroxidation. Dobutamine was a more powerful inhibitor of iron-catalyzed lipid peroxidation than the other agents, suggesting that part of the antioxidant activity of dobutamine is due to chelating iron. In addition, the catechol derivatives scavenged not only diphenylpicrylhydrazyl (DPPH) free radicals, but also 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cations and 2,2'-azobis-(2-amidinopropane)-dihydrochloride (AAPH) peroxyl radicals, indicating that the antioxidative activities of these agents are evidently due to scavenging free radicals. However, the rate constant of these catechol derivatives in scavenging hydroxyl radicals was < 10(10) M(-1) sec(-1), suggesting that they may not protect against biological damage induced by hydroxyl radicals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2001-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Antioxidant activity of adrenergic agents derived from catechol.
pubmed:affiliation
Department of Biochemistry, Hokkaido College of Pharmacy, Otaru, Japan.
pubmed:publicationType
Journal Article