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rdf:type |
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lifeskim:mentions |
umls-concept:C0015811,
umls-concept:C0017262,
umls-concept:C0019573,
umls-concept:C0034493,
umls-concept:C0040048,
umls-concept:C0175677,
umls-concept:C0185117,
umls-concept:C0205042,
umls-concept:C0336867,
umls-concept:C0392756,
umls-concept:C1135183,
umls-concept:C2911684,
umls-concept:C2936380
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pubmed:issue |
6
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pubmed:dateCreated |
1998-9-15
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pubmed:abstractText |
Tissue factor (TF) is a transmembrane glycoprotein that, after binding to factor VII/VIIa, initiates the extrinsic coagulation pathway, resulting in thrombin generation and its sequelae. Thrombin has been shown to induce TF mRNA in endothelium, monocytes, and smooth muscle cells, further perpetuating the thrombogenic cycle. This study was designed to determine the effect of specific inhibition of thrombin by recombinant hirudin (r-hirudin) on TF distribution after balloon angioplasty in the cholesterol-fed rabbit femoral artery and porcine coronary artery models.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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|
pubmed:issn |
0009-7322
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|
pubmed:author |
pubmed-author:BadimonJ JJJ,
pubmed-author:BanaiSS,
pubmed-author:BarryW LWL,
pubmed-author:ChesebroJ HJH,
pubmed-author:FallonJ TJT,
pubmed-author:FusterVV,
pubmed-author:GalliHH,
pubmed-author:GertzS DSD,
pubmed-author:GimpleL WLW,
pubmed-author:NaiduS SSS,
pubmed-author:NemersonYY,
pubmed-author:SarembockI JIJ,
pubmed-author:TaubmanM BMB,
pubmed-author:ThiruvikramanSS
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pubmed:issnType |
Print
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pubmed:day |
11
|
|
pubmed:volume |
98
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
580-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9714116-Angioplasty, Balloon,
pubmed-meshheading:9714116-Animals,
pubmed-meshheading:9714116-Cholesterol, Dietary,
pubmed-meshheading:9714116-Coronary Vessels,
pubmed-meshheading:9714116-Digoxigenin,
pubmed-meshheading:9714116-Factor VIIa,
pubmed-meshheading:9714116-Femoral Artery,
pubmed-meshheading:9714116-Hirudins,
pubmed-meshheading:9714116-Male,
pubmed-meshheading:9714116-Rabbits,
pubmed-meshheading:9714116-Recombinant Proteins,
pubmed-meshheading:9714116-Swine,
pubmed-meshheading:9714116-Thrombin,
pubmed-meshheading:9714116-Thromboplastin,
pubmed-meshheading:9714116-Tunica Intima,
pubmed-meshheading:9714116-Wounds and Injuries
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pubmed:year |
1998
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|
pubmed:articleTitle |
Hirudin reduces tissue factor expression in neointima after balloon injury in rabbit femoral and porcine coronary arteries.
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|
pubmed:affiliation |
Department of Anatomy and Cell Biology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. gertz@cc.huji.ac.il
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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