Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-9-14
|
| pubmed:abstractText |
We studied the seroprevalence and transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8), among 215 Ugandan children, adolescents and young adults. We measured antibodies to a latent nuclear antigen (LANA) and a lytic cycle protein encoded by open reading frame (orf) 65. Infection with KSHV/HHV8 occurred during early childhood and reached adult levels (approx. 50%) before the age of puberty. In children younger than 12 years of age, antibodies to LANA and the orf65 protein were independently associated with hepatitis B infection (p < 0.005). KSHV/HHV8 infection was not associated with antibodies to hepatitis A virus and hepatitis C virus, nor with the quality of the water supply, household size, previous blood transfusions, number of boy/girl friends or marital status. Antibodies to the orf65 protein, but not LANA, were weakly associated with a history of i.v. injections. Our results show that, in contrast to its sexual mode of transmission among homo/bisexual men and sexually transmitted diseases clinic attendees of Northern Europe and the US, transmission of KSHV in Uganda occurs largely before puberty. Among Ugandan children, KSHV transmission follows a horizontal pattern similar to other herpesviruses, in particular the related gamma herpesvirus, Epstein-Barr virus. Transmission of KSHV may be facilitated by living conditions that also promote infection with hepatitis B virus.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
11
|
| pubmed:volume |
77
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
817-20
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9714046-Adolescent,
pubmed-meshheading:9714046-Adult,
pubmed-meshheading:9714046-Age Distribution,
pubmed-meshheading:9714046-Age of Onset,
pubmed-meshheading:9714046-Antibodies, Viral,
pubmed-meshheading:9714046-Child,
pubmed-meshheading:9714046-Child, Preschool,
pubmed-meshheading:9714046-Cross-Sectional Studies,
pubmed-meshheading:9714046-Disease Transmission, Infectious,
pubmed-meshheading:9714046-Female,
pubmed-meshheading:9714046-Herpesviridae Infections,
pubmed-meshheading:9714046-Herpesvirus 8, Human,
pubmed-meshheading:9714046-Humans,
pubmed-meshheading:9714046-Infant,
pubmed-meshheading:9714046-Male,
pubmed-meshheading:9714046-Prevalence,
pubmed-meshheading:9714046-Sarcoma, Kaposi,
pubmed-meshheading:9714046-Uganda,
pubmed-meshheading:9714046-Viral Proteins
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents.
|
| pubmed:affiliation |
Division of Tropical Medicine, Liverpool School of Tropical Medicine, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|