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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-8-31
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pubmed:abstractText |
The MLL gene on chromosome 11q23 is frequently disrupted by chromosomal translocations in association with haematological malignancies. Recently, a specific site within the 8.3 kb MLL break-point cluster region that is cleaved during the early stages of apoptosis has been identified. Because MLL gene rearrangements are used to identify patients with high risk leukaemia, it was the aim of this study to determine whether this DNA cleavage event could be triggered in diagnostic bone marrow samples solely through ex vivo incubation at room temperature.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-1303259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-1423624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-1423625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-1465401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-14731429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-1720549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-4214419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-7014501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8069905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8103189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8164041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8253089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8260707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8282816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8309246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8361504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8481506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8481519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8558942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8634439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8636788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8639880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-8709635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-9045301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-9045303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-9058751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-9168430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9713591-9199342
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1366-8714
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
85-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9713591-Blotting, Southern,
pubmed-meshheading:9713591-Bone Marrow,
pubmed-meshheading:9713591-Child,
pubmed-meshheading:9713591-Chromosomes, Human, Pair 11,
pubmed-meshheading:9713591-Cryopreservation,
pubmed-meshheading:9713591-Culture Techniques,
pubmed-meshheading:9713591-DNA-Binding Proteins,
pubmed-meshheading:9713591-Female,
pubmed-meshheading:9713591-Gene Rearrangement,
pubmed-meshheading:9713591-Humans,
pubmed-meshheading:9713591-Infant,
pubmed-meshheading:9713591-Leukemia,
pubmed-meshheading:9713591-Male,
pubmed-meshheading:9713591-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:9713591-Neoplasm Proteins,
pubmed-meshheading:9713591-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:9713591-Proto-Oncogenes,
pubmed-meshheading:9713591-Specimen Handling,
pubmed-meshheading:9713591-Transcription Factors,
pubmed-meshheading:9713591-Zinc Fingers
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pubmed:year |
1998
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pubmed:articleTitle |
Pseudo-rearrangement of the MLL gene at chromosome 11q23: a cautionary note on genotype analysis of leukaemia patients.
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pubmed:affiliation |
Department of Molecular Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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